東田  一彦 (ヒガシダ カズヒコ)

HIGASHIDA Kazuhiko

写真a

職名

准教授

研究分野・キーワード

運動生理・生化学、スポーツ栄養

メールアドレス

メールアドレス

ホームページ

https://naoyanakai.wixsite.com/ex-nutrition

出身大学院 【 表示 / 非表示

  • 早稲田大学  スポーツ科学研究科  博士課程  2010年03月

取得学位 【 表示 / 非表示

  • 博士(スポーツ科学)  早稲田大学  2011年03月

学内職務経歴 【 表示 / 非表示

  • 滋賀県立大学  人間文化学部  生活栄養学科  准教授   2015年04月 ~ 現在

 

論文 【 表示 / 非表示

  • Low-carbohydrate high-protein diet diminishes the insulin response to glucose load via suppression of SGLT-1 in mice

    Higashida K, Terada S, Li X, Inoue S, Iida N, Kitai S, Nakai N

     Biosci Biotechnol Biochem    2018年10月

    共著  

  • Time Course of Decrease in Skeletal Muscle Mitochondrial Biogenesis after Discontinuation of High-Fat Diet.

    Li X, Higashida K, Kawamura T, Higuchi M

     J Nutr Sci Vitaminol (Tokyo)    2018年06月

    10.3177/jnsv.64.233.  共著  

  • Effects of exhaustive exercises, with different intensities, on oxidative stress markers in rat plasma and skeletal muscle

    Kawamura T., Fujii R., Li X., Higashida K., Muraoka I.

    Science and Sports  Science and Sports  33 (3)   169 ~ 175  2018年06月

    10.1016/j.scispo.2017.08.008  共著  

    [概要]

    © 2017 Elsevier Masson SAS Objectives: The purpose of this study was to examine the effects of exhaustive exercises, with different intensities, on oxidative stress markers in rat plasma and skeletal muscle. Methods: Male Sprague-Dawley rats (n = 24) were randomly divided into the following four groups: control (CON), low-intensity exercise (LE), high-intensity interval exercise (HE) and incremental exercise (IE). The animals in the latter three groups performed exercises in which they ran until exhaustion as follows: Animals in the LE group ran at 20 m/min (6° graded); the HE group ran at 40 m/min for 30 s (0° graded) with a rest interval of 60 s between each run; and the IE group ran at 15 m/min (6° graded), initially, with the running speed gradually increased by 5 m/min, every 10 min. Immediately following the exercise, a blood sample was drawn, and followed by the gastrocnemius muscle and liver were quickly removed. These samples were analysed for lactate concentration, oxidative stress markers, and glycogen contents. Results: Plasma oxidative stress markers in the LE and HE groups demonstrated no change, while plasma protein carbonyl (PC) levels and total antioxidant capacity (TAC) in the IE group were significantly increased compared with the CON group (P < 0.05). In contrast, all the oxidative stress markers, in the skeletal muscle of the three exercise groups, demonstrated no change compared with the CON group. Conclusion: Incremental exhaustive exercise elevates the plasma PC levels and TAC, but does not change skeletal muscle oxidative stress markers in rats.

  • Effects of rapid or slow body weight reduction on intramuscular protein degradation pathways during equivalent weight loss on rats

    Nonaka Y., Urashima S., Inai M., Nishimura S., Higashida K., Terada S.

    Physiological Research  Physiological Research  66 (5)   823 ~ 831  2017年01月

    共著  

    [概要]

    © 2017 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. The purpose of this study was to compare the effects of shortterm fasting-induced rapid weight loss with those of slower but equivalent body weight loss induced by daily calorie restriction on muscle protein degradation pathways and muscle protein content. Male Fischer rats were subjected to either 30 % calorie restriction for 2 weeks to slowly decrease body weight (Slow) or 3-day fasting to rapidly decrease body weight by a comparable level of that of the Slow group (Rapid). The final body weights were about 15 % lower in both the Slow and Rapid groups than in the Con group (p < 0.001). The total protein content and wet weight of fast-twitch plantaris muscle, but not slow-twitch soleus muscle, were significantly lower in the Rapid group compared with the control rats fed ad libitum. Substantial increases in the expression ratio of autophagosomal membrane proteins (LC3-II/-I ratio) and polyubiquitinated protein concentration, used as biomarkers of autophagy-lysosome and ubiquitinproteasome activities, respectively, were observed in the plantaris muscle of the Rapid group. Moreover, the LC3-II/-I ratio and polyubiquitinated protein concentration were negatively correlated with the total protein content and wet weight of plantaris muscle. These results suggest that short-term fastinginduced rapid body weight loss activates autophagy-lysosome and ubiquitin-proteasome systems more strongly than calorie restriction-induced slower weight reduction, resulting in muscular atrophy in fast-twitch muscle.

  • PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise

    Koh JH, Hancock CR, Terada S, Higashida K, Holloszy JO, Han DH

     Cell Metab  25 (5)   1176 ~ 1185  2017年

    10.1016/j.cmet.2017.04.029  共著  

  • A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer

    Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Hamaoka T, Tabata I

     Med Sci Sports Exerc    2017年

    10.1249/MSS.0000000000001312  共著  

  • 酪酸摂取がラット骨格筋における糖輸送体GLUT-4タンパク質の発現量に及ぼす影響

    野中雄大, 東田一彦, 木村典代, 寺田 新

     体力科学  65 (1)   169 ~ 176  2016年

    共著  

  • Alternate-Day High-Fat Diet Induces an Increase in Mitochondrial Enzyme Activities and Protein Content in Rat Skeletal Muscle

    Li X, Higashida K, Kawamura T, Higuchi M

     Nutrients  8 (4)   E203 ~  2016年

    10.3390/nu8040203  共著  

  • PGC-1α mediates a rapid, exercise-induced downregulation of glycogenolysis in rat skeletal muscle

    Kim SH, Koh JH, Higashida K, Jung SR, Holloszy JO, Han DH

     J Physiol  593 (3)   635 ~ 643  2015年

    共著  

  • 異なる脂質含量の食餌がラットの骨格筋ミトコンドリア酵素活性および持久性運動パフォーマンスに及ぼす影響

    東田一彦, 園生智広, 藤本恵理, 樋口満

     スポーツ科学研究  12   137 ~ 144  2015年

    共著  

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総説・解説記事 【 表示 / 非表示

研究シーズ 【 表示 / 非表示

  • 身体運動によるエネルギー代謝亢進機序に関する研究

 
 

学部講義等担当 【 表示 / 非表示

  • 健康・体力科学Ⅰ

  • 運動と健康

  • 健康・体力科学Ⅱ