東田  一彦 (ヒガシダ カズヒコ)

HIGASHIDA Kazuhiko

写真a

職名

准教授

研究分野・キーワード

運動生理・生化学、スポーツ栄養

メールアドレス

メールアドレス

ホームページ

https://naoyanakai.wixsite.com/ex-nutrition

出身大学院 【 表示 / 非表示

  • 早稲田大学  スポーツ科学研究科  博士課程  2010年03月

取得学位 【 表示 / 非表示

  • 博士(スポーツ科学)  早稲田大学  2011年03月

学内職務経歴 【 表示 / 非表示

  • 滋賀県立大学  人間文化学部  生活栄養学科  准教授   2015年04月 ~ 現在

所属学会・委員会 【 表示 / 非表示

  • 日本体力医学会  

  • 日本栄養・食糧学会  

  • 日本スポーツ栄養学会  

  • 日本アミノ酸学会  

 

論文 【 表示 / 非表示

  • Ketogenic diet feeding improves aerobic metabolism property in extensor digitorum longus muscle of sedentary male rats

    Ogura Y, Kakehashi C, Yoshihara T, Kurosaka M, Kakigi R, Higashida K, Fujiwara SE, Akema T, Funabashi T.

     Plos one    2020年10月

    10.1371/journal.pone.0241382. eCollection 2020.  共著  共同(副担当)

  • Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes

    Higashida K., Inoue S., Nakai N.

    Biochemical and Biophysical Research Communications  Biochemical and Biophysical Research Communications    2020年08月

    10.1016/j.bbrc.2020.07.041  共著  

    [概要]

    © 2020 Elsevier Inc. Iron deficiency anemia indicates poor nutrition and is a public health problem. Iron deficiency is also associated with muscle weakness. However, the intracellular mechanisms by which iron deficiency induces muscle weakness are obscure. The purpose of the present study was to evaluate the effect of iron deficiency on protein synthesis in basal and branched-amino acids (BCAA)- and insulin-stimulated state in muscle cells. Differentiated C2C12 myotubes were incubated with an iron chelator, deferoxamine mesylate, and then stimulated with BCAA or insulin to activate protein synthesis. This iron deprivation resulted in a significant reduction in the abundance of iron-containing proteins, such as the mitochondrial complex 1 subunit protein, compared to control cells, but not of protein that does not contain iron, such as citrate synthase. Proteins involved in glucose utilization, such as glucose transpoter-1, hexokinase and AMP-activated protein kinase (AMPK), were upregulated under iron deficiency. Additionally, rates of BCAA- and insulin-stimulated protein synthesis, measured by puromycin incorporation, were lower in iron-deficient myotubes than in control cells. We suggest that low iron availability attenuates BCAA- and insulin-stimulated protein synthesis, possibly via activation of AMPK in myotubes. The present findings advance the understanding of the importance of iron to skeletal muscle protein synthesis and, thus, may contribute to the prevention of sarcopenia and frailty.

  • Iron deficiency attenuates catecholamine-stimulated lipolysis via downregulation of lipolysis-related proteins and glucose utilization in 3T3-L1 adipocytes

    Higashida K, Takeuchi N, Inoue N, Hashimoto T, Nakai N

     Molecular Medicine Reports    2020年03月

    共著  

  • Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

    Kawamura T, Higashida K, Muraoka I

     Oxidative Medicine and Cellular Longevity    2020年01月

    共著  

  • Induction of Autophagy and Changes in Cellular Metabolism in Glucose Starved C2C12 Myotubes

    Naoya Nakai, Saki Kitai, Noriko Iida, Sachika Inoue, Ken Nakata, Taro Murakami, Kazuhiko Higashida

     J Nutr Sci Vitaminol (Tokyo) .  66 (1)   41 ~ 47  2020年01月

    共著  共同(副担当)

  • Low-carbohydrate high-protein diet diminishes the insulin response to glucose load via suppression of SGLT-1 in mice

    Higashida K, Terada S, Li X, Inoue S, Iida N, Kitai S, Nakai N

     Biosci Biotechnol Biochem    2018年10月

    共著  

  • Time Course of Decrease in Skeletal Muscle Mitochondrial Biogenesis after Discontinuation of High-Fat Diet.

    Li X, Higashida K, Kawamura T, Higuchi M

     J Nutr Sci Vitaminol (Tokyo)    2018年06月

    10.3177/jnsv.64.233.  共著  

  • Effects of exhaustive exercises, with different intensities, on oxidative stress markers in rat plasma and skeletal muscle

    Kawamura T., Fujii R., Li X., Higashida K., Muraoka I.

    Science and Sports  Science and Sports  33 (3)   169 ~ 175  2018年06月

    10.1016/j.scispo.2017.08.008  共著  

  • Leucine supplementation after mechanical stimulation activates protein synthesis via L-type amino acid transporter 1 in vitro

    Nakai N, Kawano F, Murakami T, Nakata K, Higashida K.

     J Cell Biochem  119 (2)   2094 ~ 2101  2018年02月

    共著  共同(副担当)

  • Effects of rapid or slow body weight reduction on intramuscular protein degradation pathways during equivalent weight loss on rats

    Nonaka Y., Urashima S., Inai M., Nishimura S., Higashida K., Terada S.

    Physiological Research  Physiological Research  66 (5)   823 ~ 831  2017年01月

    共著  

全件表示 >>

研究シーズ 【 表示 / 非表示

  • 身体運動によるエネルギー代謝亢進機序に関する研究

 
 

学部講義等担当 【 表示 / 非表示

  • 健康・体力科学Ⅰ   2015年04月 ~ 現在

  • 健康・体力科学Ⅱ   2015年04月 ~ 現在

  • 運動と健康   2015年04月 ~ 現在