田中 大也 (タナカ マサヤ)

TANAKA Masaya

写真a

職名

講師

学内職務経歴 【 表示 / 非表示

  • 滋賀県立大学  人間文化学部  生活栄養学科  講師   2020年04月 ~ 現在

 

論文 【 表示 / 非表示

  • Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad

    Endo H., Inoue I., Masunaka K., Tanaka M., Yano M.

    Bioscience, Biotechnology and Biochemistry  Bioscience, Biotechnology and Biochemistry  84 (12)   2440 ~ 2447  2020年12月

    10.1080/09168451.2020.1808443  共著  

    [概要]

    The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade.

研究シーズ 【 表示 / 非表示

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