研究者詳細 - 佐野　光枝

論文 - 佐野　光枝

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Maternal Nutrient Restriction Disrupts Gene Expression and Metabolites Associated with Urea Cycle, Steroid Synthesis, Glucose Homeostasis, and Glucuronidation in Fetal Calf Liver 査読国際誌

Susumu Muroya, Yi Zhang, Kounosuke Otomaru, Kazunaga Oshima, Ichiro Oshima, Mitsue Sano, Sanggun Roh, Koichi Ojima, Takafumi Gotoh

Metabolites 2022年2月

Maternal Nutrition During Gestation Alters Histochemical Properties, and mRNA and microRNA Expression in Adipose Tissue of Wagyu Fetuses 査読

Zhang Y., Otomaru K., Oshima K., Goto Y., Oshima I., Muroya S., Sano M., Roh S., Gotoh T.

Frontiers in Endocrinology 12 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Endocrinology

We hypothesized that maternal low or high nutrition would give unique effects to morphological and molecular dynamics in adipose tissue of fetus of fatty breed Wagyu (Japanese Black) cattle which produce highly marbled beef. This study aimed to determine the effects of maternal energy intake in Wagyu cows, during gestation on fetal adipose tissue development, histochemical properties, and gene and microRNA (miRNA) expression. Cows were allocated to one of two nutritional energy groups: 120% (HIGH) or 60% nutritional requirements of (LOW). Fetuses (n = 6 per treatment) were removed from pregnant cows by cesarean section at fetal age 260 ± 8 days and euthanized. Subcutaneous adipose tissue (SAT), thoracic cavity visceral adipose tissue (TVAT), and perirenal adipose tissue (PAT) were collected for analysis. In histochemical analysis, in SAT and PAT, HIGH fetuses had greater diameter of adipocytes than LOW fetuses (P<0.05). Only in SAT, LOW fetuses had more Leptin (LEP) mRNA and tended to have more Peroxisome Proliferator-Activated Receptor gamma (PPARG) CCAAT-enhancer-binding proteins alpha (CEBPA) and Glucose transporter (GLUT) 4 mRNA(P<0.10). In all SAT, TVAT, and PAT, LOW fetuses had higher levels of the brown adipose tissue (BAT) biomarkers Uncoupling Protein (UCP) 1 and PPARG coactivator (PGC) 1α mRNA than HIGH fetuses (P<0.08). Meanwhile, in the other adipose tissue, LOW fetuses had lower PPARG, CEBPA, and Zinc Finger Protein (ZFP) 423 (in TVAT and PAT), FASN (in TVAT), LEP and GLUT4 mRNA (in PAT; P<0.10). In particular, in TVAT and PAT, LOW fetuses exhibited lower expression of WAT biomarkers (PPARG and ZFP423). Differential expression of various miRNAs related to adipogenesis between the LOW and HIGH fetuses was detected in an adipose tissue-specific manner (P<0.10). Based on adipose tissue-specific effects of maternal nutrition, these findings suggested that poor maternal nutrition in Wagyu cattle increased BAT development in SAT, TVAT and PAT, while elevated maternal nutrition stimulated fetal SAT development compared with that of TVAT and PAT.

DOI： 10.3389/fendo.2021.797680

Scopus

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Effects of low and high levels of maternal nutrition consumed for the entirety of gestation on the development of muscle, adipose tissue, bone, and the organs of Wagyu cattle fetuses. 査読

Zhang Y，Otomaru K，Oshima K，Goto Y，Oshima I，Muroya S，Sano M， Saneshima R，Nagao Y，Kinoshita A，Okamura Y，Roh S，Ohtsuka A，Gotoh T

Animal Science Journal 92 ( 1 ) e13600 2021年12月

Maternal Undernutrition during Pregnancy Alters Amino Acid Metabolism and Gene Expression Associated with Energy Metabolism and Angiogenesis in Fetal Calf Muscle 査読国際誌

Muroya S, Zhang Y, Kinoshita A, Otomaru K, Oshima K, Gotoh Y, Oshima I, Sano M, Roh S, Oe M, Ojima K, Gotoh T.

Metabolites 11 ( 9 ) 582 2021年8月

Amino acid composition of amniotic fluid during the perinatal period reflects mother’s fat and carbohydrate intake 査読

Sano M., Nagura H., Ueno S., Nakashima A.

Nutrients 13 ( 7 ) 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrients

Dietary content during pregnancy is important because it is necessary for the growth of the fetus. With the assumption that the nutritional status of the fetus can be monitored by measuring amino acid concentrations in the amniotic fluid, we investigated whether the habitual dietary intake of pregnant women affected the composition of the amniotic fluid and the significance of perform-ing amniotic fluid analysis. The subjects were 34 mothers who delivered full‐term babies by cesarean section. Three biological samples were collected from the mothers: blood, cord blood, and am-niotic fluid. At the same time, the mothersʹ prenatal nutritional intake information was also rec-orded. When the amino acid contents of the samples were compared with the mothersʹ nutrient intake, many amino acids in the amniotic fluid were positively correlated with lipid intake, but not with protein intake. There was a negative correlation between lipid intake and carbohydrate intake, and the amino acid contents of the amniotic fluid were also negatively correlated with carbohydrate intake. The results of this study were consistent with those found in animal models, suggesting that the analysis of amniotic fluid may be a useful method to investigate the effects of habitual diet during human pregnancy on the fetus.

DOI： 10.3390/nu13072136

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108212792&origin=inward

子宮内胎児発育不全症モデルラットのトリプトファン代謝異常招待

佐野光枝

別冊BIO Clinica 6 ( 4 ) 127 - 129 2017年11月

子宮内胎児発育不全症モデルラットのトリプトファン代謝異常招待

佐野光枝

Medical Science Digest 43 ( 12 ) 2 - 4 2017年11月

Maternal and fetal tryptophan metabolism in gestating rats: effects of intrauterine growth restriction. 査読国際誌

Sano M, Ferchaud-Roucher V, Kaeffer B, Poupeau G, Castellano B & Darmaun D.

Amino Acids 48 ( 1 ) 281 - 290 2016年1月

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro. 査読国際誌

Sekine A, Okamoto M, Kanatani Y, Sano M, Shibata K, Fukuwatari T.

Springerplus 48 ( 4 ) 2015年2月

Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites. 査読

Hiratsuka C, Sano M, and Fukuwatari T, Shibata K.

Journal of Nutritional Science and Vitaminology 60 ( 4 ) 255 - 260 2014年10月

The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats. 査読

Shibata K, Ohno T, Sano M, and Fukuwatari T.

Journal of Nutritional Science and Vitaminology 60 ( 4 ) 261 - 268 2014年10月

Simultaneous measurement of nicotinamide and its catabolites, nicotinamide N-oxide, N1-methyl-2-pyridone-5-carboxamide, and N1-methyl-4-pyridone-3-carboxamide in mice urine.. 査読

Maeta A, Sano M, Fukuwatari T, and Shibata K.

Bioscience, biotechnology, and biochemistry 78 ( 8 ) 1306 - 1309 2014年6月

Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis.

Nomura K, Tatsumi S, Miyagawa A, Shiozaki Y, Sasaki S, Kaneko I, Ito M, Kido S, Segawa H, Sano M, Fukuwatari T, Shibata K, Miyamoto K.

Journal of the American Society of Nephrology 25 ( 4 ) 761 - 772 2014年4月

Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice. 査読

Maeta A, Sano M, Fukuwatari T, Funakoshi H, Nakamura T, and Shibata K.

Bioscience, biotechnology, and biochemistry 78 ( 5 ) 878 - 881 2014年3月

Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry. 査読

Sano M, Ferchaud-Roucher V, Nael C, Aguesse A, Poupeau G, Castellano B, Darmaun D.

Journal of mass spectrometry 49 ( 2 ) 128 - 135 2014年2月

High protein intake is associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study. 査読

Kobayashi S, Asakura K, Suga H, Sato-Mito N, Fujimoto E, Nakamura H, Awata S, Hoshino T, Watanabe T, Suzuki A, Mori K, Manabe Y, Matsuda H, Imai T, Murakami M, Koda T, Kogirima M, Kikuchi K, Nemoto A, Hayabuchi H, Kimura Y, Iwami M, Tsuchiya H, Nishimura K, Minamino K, Murata M, Kito H, Tanaka R, Tejima T, Tanaka H, Niizawa Y, Miyamaru K, Kamitsubo Y, Miyata S, Kanouchi H, Shimizu R, Saito M, Hori Y, Nakajima K, Tsugita K, Murakawa M, Watanabe H, Uenishi K, Shindo T, Oyama N, Arimura E, Yamashita M, Kodama K, Sumizawa T, Sagara T, Gakuin K, Komatsu Y, Teramoto F, Kitamori K, Maruyama S, Kohri T, Kaba N, Asano Y, Asahi K, Takahashi T, Kasahara Y, Hirata H, Misumi Y, Yamamura R, Yamashita H, Matsunaga T, Yamaguchi N, Miura S, Miyazaki S, Mizuno Y, Miyake M, Kaneko M, Tokudome C, Hirota N, Okishima N, Mizuno N, Miyahara K, Dokai K, Oyama T, Yoshioka Y, Nakazawa H, Sato A, Tsuji T, Okami Y, Tsuda H, Imai K, Moriguchi R, Shinohara K, Murayama N, Kushida O, Sawano K, Horita N, Yasutake K, Kubota M, Nakata K, Higashine Y, Kurokawa M, Taniguchi N, Hashimoto H, Mori H, Takagi A, Aoyama S, Honda M, Komatsu S, Iwase Y, Uesugi S, Kobayashi M, Hikosaka R, Moriwaki H, Minami H, Nakashima N, Ishii S, Yasukawa S, Kintaka Y, Aoki M, Teraoka C, Tsumura N, Nakata M, Ikemoto S, Hiroki N, Kawano N, Osawa K, Kawakami I, Ohki K, Shiga S, Ebisawa H, Funahashi Y, Nagahata T, Mita Y, Tsudzuki J, Yoshizawa K, Tanaka M, Ayabe S, Kanbe M, Hirakata C, Suzuki J, Sato K, Shibata K, Fukuwatari T, Sano M, Ichikawa Y, Morooka M, Saito N, Nishiyama R, Tanaka H, Oka J, Sekiguchi N, Wada R, Shioiri T, Notsu A, Harada S, Ohmori A, Kuwamori T, Ota M, Yano T, Sato A, Sekine M, Abe C, Watanabe R, Muramatsu K, Takeda E, Yamanaka-Okumura H, Adachi C, Takahashi Y, Yaguchi Y, Suizu K, Shigeta M, Fukasawa S, Fujii M, Sakuma A, Arao K, Kato T., Sasaki S

Nutrition journal 12 164 2013年12月

L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental, and fetal growth.

Tsuji A, Nakata C, Sano M, Fukuwatari T, Shibata K.

International journal of tryptophan research 6 21 - 33 2013年8月

Urinary excretion levels of water-soluble vitamins in pregnant and lactating women in Japan.

Shibata K, Fukuwatari T, Sasaki S, Sano M, Suzuki K, Hiratsuka C, Aoki A, Nagai C.

Journal of Nutritional Science and Vitaminology 59 ( 3 ) 173 - 186 2013年7月

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase. 査読

Terakata M, Fukuwatari T, Kadota E, Sano M, Kanai M, Nakamura T, Funakoshi H, Shibata K.

The Journal of nutrition 143 ( 7 ) 1046 - 1051 2013年7月

Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects. 査読

Hiratsuka C, Fukuwatari T, Sano M, Saito K, Sasaki S, Shibata K.

The Journal of nutrition 143 ( 6 ) 859 - 866 2013年6月

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