Updated on 2022/11/11

写真a

 
YANO Mihiro
 
Organization
Faculty of Human Cultures
Department
School of Human Cultures Department of Nutrition
Title
Professor
External link

Education

  • Hirosaki University   Faculty of Medicine

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    Country: Japan

Degree

  • 博士(医学) ( 1998.3   徳島大学 )

Research Experience

  • The University of Shiga Prefecture   Professor

    2012.4

Available Technology

  • 食品成分を基にした新規抗癌剤の開発に向けて…

Papers

  • Hesperetin induces apoptosis in A549 cells via the Hsp70-mediated activation of Bax Reviewed International journal

    Masaya Tanaka, Hiroshi Endo, Konatsu Sakusa, Mihiro Yano

    International Journal of Oncology   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

    DOI: 10.3892/ijo.2022.5433

  • Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad Reviewed

    Endo H., Inoue I., Masunaka K., Tanaka M., Yano M.

    Bioscience, Biotechnology and Biochemistry   84 ( 12 )   2440 - 2447   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Bioscience, Biotechnology and Biochemistry  

    The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade.

    DOI: 10.1080/09168451.2020.1808443

    Scopus

    Other Link: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089869160&origin=inward

  • Relationship between dietary patterns and brachial-ankle pulse wave velocity among middle-aged aduluts in Japan Reviewed International journal

    Moyama S, Minami K, Yano M, Okumura M, Hayashi S, Takayama H, Yorimoto A

    Asia Oac J Clin Nutr   26 ( 3 )   539 - 544   2017

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.6133/apjcn.032016.14

  • Influenza A virus infection of vascular endothelial cells induces GSK-3β-mediated β-catenin degradation in adherens junctions, with a resultant increase in membrane permeability. Reviewed International journal

    Hiyoshi M, Indalao IL, Yano M, Yamane K, Takahashi E, Kido H.

    Archi Virol   160 ( 1 )   225 - 234   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.1007/s00705-014-2270-5

  • Ibuprofen Enhances the Anti-cancer Activity of Cisplatin in Lung Cancer Cells by Inhibiting the Heat Shock Protein 70 Reviewed

    Endo H, Yano M, Okumura Y, Kido H.

    Cell Death and Disease   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature Publishing groop   Participation form:Joint(The main charge)  

    DOI: 10.1038/cddis.2013.550.

  • Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo Reviewed

    Inoue M, Yasuda K, Uemura H, Yasaka N, Schnaufer A, Yano M, Kido H, Kohda D, Doi H, Fukuma T, Tsuji A, Horikoshi N.

    Journal of Biochemistry   153 ( 5 )   431 - 439   2013.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford Journals   Participation form:Joint(The vice charge)  

    DOI: 10.1093/jb/mvt016. Epub 2013 Mar 1.

  • Induction and maintenance of anti-influenza antigen-specific nasal secretory IgA levels and serum IgG levels after influenza infection in adults. Reviewed

    Fujimoto C et al.

    Influenza Other Respir Viruses   Nov 6 ( 6 )   396 - 403   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.1111/j.1750-2659.2011.00330.x. Epub 2012 Jan 6.

  • Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure. Reviewed

    Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Yao D, Yao M, Chida J, Yano M.

    Biochim Biophys Acta   1824 ( 1 )   186 - 194   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

    DOI: 10.1016/j.bbapap.2011.07.001. Epub 2011 Jul 23.

  • Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity. Reviewed

    Mizuno D, Kimoto T, Takei T, Fukuta A, Shinahara W, Takahashi E, Yano M, Kido H.

    Vaccine   29 ( 33 )   5368 - 5378   2011.7

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.1016/j.vaccine.2011.05.090. Epub 2011 Jun 12.

  • Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis. Reviewed

    Pan HY, Yamada H, Chida J, Wang S, Yano M, Yao M, Zhu J, Kido H.

    Cardiovascular Research   89 ( 3 )   595 - 603   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford Journals   Participation form:Joint(The vice charge)  

    DOI: 10.1093/cvr/cvq358. Epub 2010 Nov 16.

  • Effects of inhibitors of Toll-like receptors, protease-activated receptor-2 signalings and trypsin on influenza A virus replication and upregulation of cellular factors in cardiomyocytes Reviewed

    Pan HY, Yano M, Kido H.

    Journal Of Medical Investigation   58 ( 1-2 )   19 - 28   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

  • Influenza virus-cytokine-protease cycle in the pathogenesis of vascular hyperpermeability in severe influenza. Reviewed

    Wang S, Le TQ, Kurihara N, Chida J, Cisse Y, Yano M, Kido H.

    The Journal of Infectious Disease   202 ( 7 )   991 - 1001   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford Journals   Participation form:Joint(The main charge)  

    DOI: 10.1086/656044.

  • Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. Reviewed

    Okumura Y, Takahashi E, Yano M, Ohuchi M, Daidoji T, Nakaya T, Böttcher E, Garten W, Klenk HD, Kido H.

    Journal of Virology   84 ( 10 )   5089 - 5096   2010.5

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.1128/JVI.02605-09. Epub 2010 Mar 10.

  • Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection. Reviewed

    Wang S, Quang Le T, Chida J, Cisse Y, Yano M, Kido H.

    Journal Of Medical Investigation   57 ( 1-2 )   26 - 34   2010.2

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  • Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses. Reviewed

    Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M.

    Journal of Molecular and Genetic Medicine   3 ( 1 )   167 - 175   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

  • Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. Reviewed

    Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, Kido H.

    Journal of NeuroVirology   14 ( 3 )   186 - 195   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

    DOI: 10.1080/13550280801993630.

  • Gatekeeper role of 14-3-3tau protein in HIV-1 gp120-mediated apoptosis of human endothelial cells by inactivation of Bad. Reviewed

    Yano M, Nakamuta S, Shiota M, Endo H, Kido H.

    AIDS   21 ( 8 )   911 - 920   2007.5

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

  • Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents. Reviewed

    Kido H, Okumura Y, Yamada H, Le TQ, Yano M.

    Current Pharmaceutical Design   13 ( 4 )   405 - 414   2007

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  • Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. Reviewed

    Okumura Y, Hayama M, Takahashi E, Fujiuchi M, Shimabukuro A, Yano M, Kido H.

    Biochemical Journal   400 ( 3 )   551 - 561   2006.12

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

  • A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins. Reviewed

    Yano M, Nakamuta S, Wu X, Okumura Y, Kido H.

    Molecular Biology of the Cell   17 ( 11 )   4769 - 4779   2006.11

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    DOI: 10.1091/mbc.E06-03-0229

  • Chaperone activities of the 26S and 20S proteasome. Reviewed

    Yano M, Kanesaki Y, Koumoto Y, Inoue M, Kido H.

    Current Protein and Peptide Science   6 ( 2 )   197 - 203   2005.4

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  • Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential. Reviewed

    Kido H, Okumura Y, Yamada H, Mizuno D, Higashi Y, Yano M.

    Biological Chemistry   ( 11 )   1029 - 1034   2004.11

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  • 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. Reviewed

    Yano M, Koumoto Y, Kanesaki Y, Wu X, Kido H.

    Biomacromolecules   5 ( 4 )   1465 - 1469   2004.7

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  • Endothelin-1 peptides and IL-5 synergistically increase the expression of IL-13 in eosinophils.

    Cui P, Sharmin S, Okumura Y, Yamada H, Yano M, Mizuno D, Kido H.

    Biochem Biophys Res Commun.   318 ( 3 )   782 - 787   2004.6

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  • The second metal-binding site of 70kDa heat-shock protein is essential for ADP-binding, ATP hydrolysis and ATP synthesis Reviewed

    X Wu, M Yano, H Washida, H Kido

    The Biochemical Journal   378   793 - 799   2004

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  • RNA interference of valosin containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome dependent proteolysis

    C Wojcik, M Yano, GN DeMartino

    Journal of Cell Science   117   281 - 292   2004

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  • Binding of a new bioactive 31 amino acid endothelin-1 to an endothelin B of B-like receptor in porcine lungs Reviewed

    H Kitamura, P Cui, S Sharmin, M Yano, H kido

    European Journal of Pharmacology   465   31 - 38   2003

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  • The effect of topically applied secretory leukocyte protease inhibitor on the eosinophil response in the late phase of allergic conjunctivitis Reviewed

    E Murata, S Sharmin, H Shiota, M Shiiota, M Yano, H Kido

    Current Eye Research   26 ( 5 )   271 - 276   2003

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

  • Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels Reviewed

    B Yang, DF Yao, M Ohuchi, M Ide, M Yano, Y Okumura, H Kido

    The European Respiratory Journal   19 ( 5 )   952 - 958   2002

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  • A novel bioactive 31-amino acid endothelin-1 peptide stimulates eosinophil recruitment, and increases the level of eotaxin and IL-5 Reviewed

    S Sharmin, M Shiota, E Murata, P Cui, H Kitamura, M Yano, H Kido

    Inflammation Research   51 ( 4 )   195 - 200   2002

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  • A novel-bioactive31-amino acid endothelin-1 is a potent chemotactic peptide for human neutrophils and monocytes Reviewed

    P Cui, K Tani, H Kitamura, Y Okumura, M Yano, D Inui, T Tamaki, S Sone, H Kido

    Journal of Leukocyte Biology   70 ( 2 )   306 - 312   2001

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  • Increased concentrations of 14-3-3 ε, γ and ζ isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction Reviewed

    H Wakabayashi, M Yano, N Tachi-kawa, S Oka, M Maeda, H Kido

    Clinica Chimica Acta   312   97 - 105   2001

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  • Mast cell tryptase from pig lungs triggers infection by pneumo- tropic Sendai and influenza A viruses Reviewed

    Y Chen, M Shiota, M Ohuchi, T Towatari, J Tashiro, M Murakami, M Yano, B Yang, H Kido

    European Journal of Biochemistry   267   3189 - 3197   2000

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  • 14-3-3τ associates with a translational control factor FKBP12 rapamycin- associated protein in T cells after stimulation by pervanadate Reviewed

    H Mori, M Inoue, M Yano, H Wakabayashi, H Kido

    FEBS Letters   461 ( 7 )   61 - 64   2000

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  • The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin Reviewed

    Y Okumura, M Yano, M Murakami, T Towatari, H Kido

    FEBS Letters   442   39 - 42   1999

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  • Intrinsic nucleoside diphosphate kinase-like activity is a novel function of the 20S Reviewed

    M Yano, S Mori, H Kido

    The Journal of Biological Chemistry   274 ( 48 )   34375 - 34382   1999

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  • Specific sandwich-type enzyme immunoassays for smooth muscle constricting novel 31- amino acid endothelins Reviewed

    N Okishima, Y Hagiwara, T Seito, M Yano, H Kido

    Biochemical and Biophysical Research Communications   256 ( 1 )   1 - 5   1999

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  • Enzymatic activation of immunoglobulin binding factor in female reproductive tract Reviewed

    H Mori, M Kamada, M Maegawa, S Yamamoto, T Aono, S Futaki, M Yano, H Kido, SS Koide

    Biochemical and Biophysical Research Communications   246 ( 2 )   409 - 413   1998

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  • Novel 31-amino acid- length endothelins cause constriction of vascular smooth muscle Reviewed

    F Kishi, K Minami, N Okishima, M Murakami, S Mori, M Yano, Y Niwa, Y. Nakaya, H Kido

    Biochemical and Biophysical Research Communications   248 ( 2 )   387 - 390   1998

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  • The structure of asparagine- linked oligosaccharide of rat liver cathepsin L reflects the substrate specificityof lysosomal alpha-mannosidase Reviewed

    T Towatari, T Miyamura, A Kondo, I Kato, M Inoue, M Yano, H Kido

    European Journal of Biochemistry   256 ( 1 )   163 - 169   1998

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  • Intrinsic nucleoside diphosphate kinase-like activity as a novel function of 14-3-3 proteins Reviewed

    M Yano, S Mori, Y Niwa, M Inoue, H Kido

    FEBS Letters   419   244 - 248   1997

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  • Intrinsic ADP-ATP exchange activity is a novel function of the molecular chaperone Hsp70 Reviewed

    M Hiromura, M Yano, H Mori, M Inoue, H Kido

    The Journal of Biological Chemistry   273 ( 10 )   5435 - 5438   1997

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  • T-cell membrane-associated serine protease, tryptase TL2, binds human immuno-deficiency virus type 1 gp120 and cleaves the third-variable-domain loop of gp120 Neutra- lizing antibodies of human immuno- deficiency virus type 1 inhibit cleavage of gp120 Reviewed

    Y Niwa, M Yano, S Futaki, Y Okumura, H kido

    European Journal of Biochemistry   237   64 - 70   1996

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Books etc

  • Visual 栄養学テキスト 人体の構造と機能および疾病の成り立ちⅢ 疾病の成り立ち

    田中清,他( Role: Joint author)

    中山書店  2017.9  ( ISBN:978-4-521-74286-1

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    Total pages:182   Responsible for pages:169-176   Language:Japanese   Book type:Textbook, survey, introduction

  • カレント 人体の構造と機能及び疾病の成り立ち2

    志村二三夫, 石田均 他( Role: Joint author)

    建帛社  2015.3  ( ISBN:978-4-7679-0510-5

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    Total pages:283   Responsible for pages:69-91   Language:Japanese   Book type:Textbook, survey, introduction

  • The Ubiquitin- Proteasome System In the Central Nervous System: From Physiology To Pathology

    M Yano, H Kido( Role: Contributor)

    Nova  2007 

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    Language:English   Book type:Scholarly book

  • プロフェッショナル英和辞典SPED EOS

    堀内 克明、布山喜章他編( Role: Contributor)

    小学館  2004 

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    Language:Japanese   Book type:Dictionary, encyclopedia

  • Biomolecular Infectious and Immune Mechanisms

    H. Kido, P Cui, S Sharmin, M Shiota, D Yao, C Lin, M Yano( Role: Joint author)

    Kluwer  2003 

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    Language:English   Book type:Scholarly book

  • 神経難病の分子機構 

    木戸 博、 矢野仁康, 河本泰子( Role: Sole author)

    シェプリンガー、フェアラーク株式会社  2001 

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    Language:Japanese   Book type:Scholarly book

  • 基礎生化学実験法、タンパク質II・動態解析法

    木戸 博、 矢野仁康( Role: Joint author)

    東京化学同人  2000 

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    Language:Japanese   Book type:Textbook, survey, introduction

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MISC

  • インフルエンザ重症化と脳症の分子機構 Invited Reviewed

    矢野仁康、木戸 博

    化学療法の領域   27 ( 12 )   54 - 61   2011.12

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:医薬ジャーナル社   

Presentations

  • ヘスペレチンはHSF1を介して癌細胞の上皮間葉転換を抑制する

    田中大也,遠藤弘史,矢野仁康

    第94回日本生化学会大会  2021.11 

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    Language:English   Presentation type:Poster presentation  

  • クルクミンが有する癌細胞転移に対する抑制機能についての解析

    黒川沙貴,遠藤弘史,矢野仁康

    第94回日本生化学会大会  2021.11 

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    Language:English   Presentation type:Oral presentation (general)  

  • ヘスペレチンはHSF1の発現を抑制して肺癌幹細胞特性を低下させる

    佐草 小夏, 田中 大也, 遠藤 弘史, 矢野 仁康

    第93回日本生化学会大会  2020.9 

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  • ヘスペレチンの癌細胞及び癌幹細胞に対する新規抗癌作用の検討

    舛中 貴美子、遠藤 弘史、矢野 仁康

    第92回日本生化学会大会  2019.9 

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  • クルクミンによる浮遊癌細胞に対するアノイキス誘導メカニズムの解析ならびに癌幹細胞抑制効果の検討

    舛中 貴美子、遠藤 弘史、柘植 未来、矢野 仁康

    第92回日本生化学会大会  2019.9 

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  • カプサイシンによるp53-14-3-3σ経路を介した細胞周期停止機能についての解析

    高台 絢加、遠藤 弘史、日馬 亜希、矢野 仁康

    第92回日本生化学会大会  2019.9 

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  • カプサイシンによる新規癌細胞増殖抑制機構:14-3-3σ を介した細胞周期停止機能についての解析

    佐草小夏, 遠藤弘史, 矢野仁康

    第73回日本栄養・食糧学会大会  2019.5 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  • クルクミンによる癌細胞死誘導メカニズムの解析ならびに浮遊癌細胞に対するアノイキス誘導効果の検討

    高台 絢加、遠藤 弘史、矢野 仁康

    第73回日本栄養・食糧学会大会  2019.5 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  • 「酵素と感染症:タンパク質分解酵素によるインフルエンザ重症化機序」 Invited

    矢野仁康

    日本栄養・食糧学会   2013.10 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • The Biological Functions of 14-3-3 as a Stress Protein Invited International conference

    M Yano

    BIOLOGY OF 14-3-3 PROTEINS. Gordon Research Conferences Ventura, USA  2008.2 

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    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:CA USA  

  • A novel function of 14-3-3 protein:14-3-3ζ is a heat-shock-related molecular chaperone that dissolves thermal aggregated proteins. Invited International conference

    M Yano

    Biology of 14-3-3 proteins. Satellite Meeting, 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBM Congress, Kyoto  2006.6 

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    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:京都  

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