Updated on 2025/01/30

写真a

 
YANO Mihiro
 
Organization
Faculty of Human Cultures
Department
School of Human Cultures Department of Nutrition
Title
Professor
External link

Education

  • Hirosaki University   Faculty of Medicine

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    Country: Japan

Degree

  • 博士(医学) ( 1998.3   徳島大学 )

Research Experience

  • The University of Shiga Prefecture   Professor

    2012.4

Available Technology

  • 食品成分を基にした新規抗癌剤の開発に向けて…

Papers

  • Hesperetin induces apoptosis in A549 cells via the Hsp70-mediated activation of Bax Reviewed International journal

    Masaya Tanaka, Hiroshi Endo, Konatsu Sakusa, Mihiro Yano

    International Journal of Oncology   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

    DOI: 10.3892/ijo.2022.5433

  • Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad Reviewed

    Endo H., Inoue I., Masunaka K., Tanaka M., Yano M.

    Bioscience, Biotechnology and Biochemistry   84 ( 12 )   2440 - 2447   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Bioscience, Biotechnology and Biochemistry  

    The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade.

    DOI: 10.1080/09168451.2020.1808443

    Scopus

    Other Link: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089869160&origin=inward

  • Relationship between dietary patterns and brachial-ankle pulse wave velocity among middle-aged aduluts in Japan Reviewed International journal

    Moyama S, Minami K, Yano M, Okumura M, Hayashi S, Takayama H, Yorimoto A

    Asia Oac J Clin Nutr   26 ( 3 )   539 - 544   2017

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.6133/apjcn.032016.14

  • Influenza A virus infection of vascular endothelial cells induces GSK-3β-mediated β-catenin degradation in adherens junctions, with a resultant increase in membrane permeability. Reviewed International journal

    Hiyoshi M, Indalao IL, Yano M, Yamane K, Takahashi E, Kido H.

    Archi Virol   160 ( 1 )   225 - 234   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.1007/s00705-014-2270-5

  • Ibuprofen Enhances the Anti-cancer Activity of Cisplatin in Lung Cancer Cells by Inhibiting the Heat Shock Protein 70 Reviewed

    Endo H, Yano M, Okumura Y, Kido H.

    Cell Death and Disease   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature Publishing groop   Participation form:Joint(The main charge)  

    DOI: 10.1038/cddis.2013.550.

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Books etc

  • Visual 栄養学テキスト 人体の構造と機能および疾病の成り立ちⅢ 疾病の成り立ち

    田中清,他( Role: Joint author)

    中山書店  2017.9  ( ISBN:978-4-521-74286-1

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    Total pages:182   Responsible for pages:169-176   Language:Japanese   Book type:Textbook, survey, introduction

  • カレント 人体の構造と機能及び疾病の成り立ち2

    志村二三夫, 石田均 他( Role: Joint author)

    建帛社  2015.3  ( ISBN:978-4-7679-0510-5

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    Total pages:283   Responsible for pages:69-91   Language:Japanese   Book type:Textbook, survey, introduction

  • The Ubiquitin- Proteasome System In the Central Nervous System: From Physiology To Pathology

    M Yano, H Kido( Role: Contributor)

    Nova  2007 

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    Language:English   Book type:Scholarly book

  • プロフェッショナル英和辞典SPED EOS

    堀内 克明、布山喜章他編( Role: Contributor)

    小学館  2004 

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    Language:Japanese   Book type:Dictionary, encyclopedia

  • Biomolecular Infectious and Immune Mechanisms

    H. Kido, P Cui, S Sharmin, M Shiota, D Yao, C Lin, M Yano( Role: Joint author)

    Kluwer  2003 

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    Language:English   Book type:Scholarly book

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MISC

  • インフルエンザ重症化と脳症の分子機構 Invited Reviewed

    矢野仁康、木戸 博

    化学療法の領域   27 ( 12 )   54 - 61   2011.12

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:医薬ジャーナル社   

Presentations

  • ヘスペレチンによる大腸癌幹細胞に対する抑制効果の検討

    三橋玲奈 田中大也 遠藤弘史 矢野仁康

    第62回日本栄養・食糧学会近畿支部大会  2023.11 

  • ヘスペレチンはHSF1を介して癌細胞の上皮間葉転換を抑制する

    田中大也,遠藤弘史,矢野仁康

    第94回日本生化学会大会  2021.11 

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    Language:English   Presentation type:Poster presentation  

  • クルクミンが有する癌細胞転移に対する抑制機能についての解析

    黒川沙貴,遠藤弘史,矢野仁康

    第94回日本生化学会大会  2021.11 

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    Language:English   Presentation type:Oral presentation (general)  

  • ヘスペレチンはHSF1の発現を抑制して肺癌幹細胞特性を低下させる

    佐草 小夏, 田中 大也, 遠藤 弘史, 矢野 仁康

    第93回日本生化学会大会  2020.9 

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    Language:Japanese   Presentation type:Poster presentation  

  • ヘスペレチンの癌細胞及び癌幹細胞に対する新規抗癌作用の検討

    舛中 貴美子、遠藤 弘史、矢野 仁康

    第92回日本生化学会大会  2019.9 

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    Language:Japanese   Presentation type:Poster presentation  

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