Faculty Profiles - YANO Mihiro

Papers - YANO Mihiro

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Hesperetin induces apoptosis in A549 cells via the Hsp70-mediated activation of Bax Reviewed International journal

Masaya Tanaka, Hiroshi Endo, Konatsu Sakusa, Mihiro Yano

International Journal of Oncology 2022.12

Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad Reviewed

Endo H., Inoue I., Masunaka K., Tanaka M., Yano M.

Bioscience, Biotechnology and Biochemistry 84 ( 12 ) 2440 - 2447 2020.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Bioscience, Biotechnology and Biochemistry

The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade.

DOI： 10.1080/09168451.2020.1808443

Scopus

Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089869160&origin=inward

Relationship between dietary patterns and brachial-ankle pulse wave velocity among middle-aged aduluts in Japan Reviewed International journal

Moyama S, Minami K, Yano M, Okumura M, Hayashi S, Takayama H, Yorimoto A

Asia Oac J Clin Nutr 26 ( 3 ) 539 - 544 2017

Influenza A virus infection of vascular endothelial cells induces GSK-3β-mediated β-catenin degradation in adherens junctions, with a resultant increase in membrane permeability. Reviewed International journal

Hiyoshi M, Indalao IL, Yano M, Yamane K, Takahashi E, Kido H.

Archi Virol 160 ( 1 ) 225 - 234 2015.1

Ibuprofen Enhances the Anti-cancer Activity of Cisplatin in Lung Cancer Cells by Inhibiting the Heat Shock Protein 70 Reviewed

Endo H, Yano M, Okumura Y, Kido H.

Cell Death and Disease 2014.1

Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo Reviewed

Inoue M, Yasuda K, Uemura H, Yasaka N, Schnaufer A, Yano M, Kido H, Kohda D, Doi H, Fukuma T, Tsuji A, Horikoshi N.

Journal of Biochemistry 153 ( 5 ) 431 - 439 2013.3

Induction and maintenance of anti-influenza antigen-specific nasal secretory IgA levels and serum IgG levels after influenza infection in adults. Reviewed

Fujimoto C et al.

Influenza Other Respir Viruses Nov 6 ( 6 ) 396 - 403 2012.11

Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure. Reviewed

Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Yao D, Yao M, Chida J, Yano M.

Biochim Biophys Acta 1824 ( 1 ) 186 - 194 2012.1

Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity. Reviewed

Mizuno D, Kimoto T, Takei T, Fukuta A, Shinahara W, Takahashi E, Yano M, Kido H.

Vaccine 29 ( 33 ) 5368 - 5378 2011.7

Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis. Reviewed

Pan HY, Yamada H, Chida J, Wang S, Yano M, Yao M, Zhu J, Kido H.

Cardiovascular Research 89 ( 3 ) 595 - 603 2011.2

Effects of inhibitors of Toll-like receptors, protease-activated receptor-2 signalings and trypsin on influenza A virus replication and upregulation of cellular factors in cardiomyocytes Reviewed

Pan HY, Yano M, Kido H.

Journal Of Medical Investigation 58 ( 1-2 ) 19 - 28 2011.2

Influenza virus-cytokine-protease cycle in the pathogenesis of vascular hyperpermeability in severe influenza. Reviewed

Wang S, Le TQ, Kurihara N, Chida J, Cisse Y, Yano M, Kido H.

The Journal of Infectious Disease 202 ( 7 ) 991 - 1001 2010.10

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. Reviewed

Okumura Y, Takahashi E, Yano M, Ohuchi M, Daidoji T, Nakaya T, Böttcher E, Garten W, Klenk HD, Kido H.

Journal of Virology 84 ( 10 ) 5089 - 5096 2010.5

Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection. Reviewed

Wang S, Quang Le T, Chida J, Cisse Y, Yano M, Kido H.

Journal Of Medical Investigation 57 ( 1-2 ) 26 - 34 2010.2

Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses. Reviewed

Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M.

Journal of Molecular and Genetic Medicine 3 ( 1 ) 167 - 175 2009.1

Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. Reviewed

Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, Kido H.

Journal of NeuroVirology 14 ( 3 ) 186 - 195 2008.5

Gatekeeper role of 14-3-3tau protein in HIV-1 gp120-mediated apoptosis of human endothelial cells by inactivation of Bad. Reviewed

Yano M, Nakamuta S, Shiota M, Endo H, Kido H.

AIDS 21 ( 8 ) 911 - 920 2007.5

Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents. Reviewed

Kido H, Okumura Y, Yamada H, Le TQ, Yano M.

Current Pharmaceutical Design 13 ( 4 ) 405 - 414 2007

Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. Reviewed

Okumura Y, Hayama M, Takahashi E, Fujiuchi M, Shimabukuro A, Yano M, Kido H.

Biochemical Journal 400 ( 3 ) 551 - 561 2006.12

A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins. Reviewed

Yano M, Nakamuta S, Wu X, Okumura Y, Kido H.

Molecular Biology of the Cell 17 ( 11 ) 4769 - 4779 2006.11

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