研究者詳細 - 今井　絵理

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The association with dietary patterns and risk of anemia in japanese elderly 査読

Kito A., Imai E.

Journal of Nutritional Science and Vitaminology 66 ( 1 ) 32 - 40 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2020, Center for Academic Publications Japan. All rights reserved. Anemia is a risk factor for frailty. Although various factors can reduce the risk of anemia, information on dietary contributions is limited. This study aimed to evaluate the association between anemia and eating patterns in Japanese elderly. Our study included 6,864 elderly individuals, aged ≥65 y, whose data were obtained from the 2010–2015 National Health and Nutritional Survey, Japan. Anemia was defined as whole blood hemoglobin concentrations <13 g/dL in men, and <12 g/dL in women. We classified eating patterns into 33 food groups, using food items obtained from dietary records, and identified three dietary patterns using principal component analysis method. Participants were assigned and divided into quartiles according to pattern-specific factor scores. We calculated adjusted odds ratios (ORs) for anemia using multivariate logistic regression, and assigned the first quartile (minimum) as the reference. The overall prevalence of anemia was 17.1%. The meats and vegetables eating pattern was characterized by red meat and other vegetables, the Japanese eating pattern by rice and salted or pickled vegetables, and the fruits and vegetables eating pattern by fruits and green-yellow vegetables. Participants in the highest meats and vegetables eating pattern quartile had a 20% lower risk of anemia than those in the lowest quartile (OR 0.81; 95% confidence interval (CI) 0.66–1.00); the Japanese eating pattern participants had a 20% higher risk of anemia (OR 1.28; 95% CI 1.06–1.53). The fruits and vegetables eating pattern participants had no significant change in their risk of anemia. This study may indicate that consuming a high red meat diet prevents anemia in elderly Japanese individuals.

DOI： 10.3177/jnsv.66.32

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Fish and meat intakes and prevalence of anemia among the Japanese elderly. 査読国際誌

Imai E, Nakade M

Asia Pacific Journal of Clinical Nutrition 28 ( 2 ) 276 - 284 2019年6月

Oral glucose tolerance and tryptophan metabolism in non-obese and non-insulin-dependent diabetic goto–kakizaki rats fed high-tryptophan diets 査読

Imai E., Shibata K.

Journal of Nutritional Science and Vitaminology 64 ( 1 ) 48 - 55 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2018, Center for Academic Publications Japan. All rights reserved. We investigated oral glucose tolerance and tryptophan (Trp) metabolism in non-obese and non-insulin-dependent diabetic Goto–Kakizaki (GK) rats fed high-Trp diets. Five-week-old male Wistar and GK rats were fed a 20% casein diet (control diet) or the same diet supplemented with 1%, 2%, 3%, or 5% Trp for 58 d. Oral glucose tolerance tests were performed on Days 14 and 28 of the experimental period. Urine as well as livers and blood were collected on the last day of the experiment. The glucose concentration and the amount of Trp metabolites were measured. On Day 14 of the experiment, the incremental blood glucose concentrations integrated over a period of 2 h (∆AUC0-2h) of blood glucose in rats fed the 3% and 5% Trp diets had decreased by 13% and 18%, respectively, compared with that of the control-GK rats. However, no significant differences were found in the rats fed +1% or +2% Trp diets compared with control-GK rats. On Day 28, there were no significant differences found in the ∆AUC0-2hof blood glucose levels in any group including the control-GK group. On the last day, the concentrations of plasma glucose, total cholesterol, and triglyceride did not show differences in any group. There were no specific phenomena observed in the metabolism of Trp in GK rats even when fed an excess of Trp, compared with that of Wistar rats. Oral Trp administration and its continuous use may not improve blood glucose levels in type 2 diabetic rats.

DOI： 10.3177/jnsv.64.48

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Different Psychosocial Factors Are Associated With Different Intention and Self-Efficacy Toward Eating Breakfast Among Japanese Breakfast Skippers: A Gender Comparison 査読

Makiko Nakade, Megumi Tsubota-Utsugi, Eri Imai, Nobuyo Tsuboyama-Kasaoka, Nobuo Nishi, Hidemi Takimoto

29 ( 2 ) 102 - 113 2017年3月

Improved Prevalence of Anemia and Nutritional Status among Japanese Elderly Participants in the National Health and Nutritional Survey Japan, 2003-09. 国際誌

Imai E, Nakade M, Kasaoka T, Takimoto H

Journal of Nutrition & Food Sciences 6 ( 3 ) 2016年4月

The physical examination content of the Japanese National Health and Nutrition Survey: temporal changes. 国際誌

Tanaka H, Imai,S, Nakade M, Imai E, Takimoto H.

Asia Pacific Journal of Clinical Nutrition 25 ( 4 ) 898 - 910 2016年

Animal protein intake is associated with higher-level functional capacity in elderly adults: the Ohasama study. 査読

Imai E, Tsubota-Utsugi M, Kikuya M, Satoh M, Inoue R, Hosaka M, Metoki H, Fukushima N, Kurimoto A, Hirose T, Asayama K, Imai Y, Ohkubo T

Journal of the American Geriatrics Society 62 ( 3 ) 426 - 434 2014年3月

Animal protein intake is associated with higher-level functional capacity in the elderly: The Ohasama study.

Imai E, Tsubota-Utsugi M, Kikuya M, Satoh M, Inoue R, Hosaka M, Metoki H, Fukushima N, Kurimoto A, Hirose T, Asayama K, Imai Y, Ohkubo T.

Journal of the American Geriatrics Society 6 426 - 634 2014年

Animal protein intake is associated with higher-level functional capacity in the elderly: The Ohasama study. 査読

Imai E, Tsubota-Utsugi M, Kikuya M, Satoh M, Inoue R, Hosaka M, Metoki H, Fukushima N, Kurimoto A, Hirose T, Asayama K, Imai Y, Ohkubo T

Journal of the American Geriatrics Society 6 626 - 634 2014年

Dietary Intake of Nutrients with Adequate Intake Values in the Dietary Reference Intakes for Japanese 査読

Nobuyo Tsubyama-Kasaoka, Asuka Takizawa, Megumi Tsubota-Utsugi, Makiko Nakade, Eri Imai, Akiko Kondo, Kazue Yoshida, Nagako Okuda, Nobuo Nishi, Hidemi Takimoto

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 59 ( 6 ) 584 - 595 2013年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CENTER ACADEMIC PUBL JAPAN

The Adequate Intake (AI) values in: the Dietary Reference Intakes for Japanese (DRIs-J) 2010 were mainly determined based on the median intakes from 2 y of pooled data (2005-2006) from the National Health and Nutrition Survey-Japan (NHNS-J). However, it remains unclear whether 2 y of pooled data from the NHNS-J are appropriate for evaluating the intake of the population. To clarify the differences in nutrient intakes determined from 2 and 7 y of pooled data, we analyzed selected nutrient intake levels by sex and age groups using NHNS-J data. Intake data were obtained from 64,624 individuals (age: >= 1 y; 47.4% men) who completed a semi-weighed 1-d household dietary record that was part of the NHNS-J conducted annually in Japan from 2003 to 2009. There were no large differences between the median intakes calculated from 2 or 7 y of pooled data for n-6 or n-3 polyunsaturated fatty acids (PUFAs), vitamin D, pantothenic acid, potassium, or phosphorus. When the AI values and median intakes were compared, there was no large difference in the values for n-6 or n-3 PUFAs, pantothenic acid, or phosphorus. Conversely, the AI values for vitamin D and potassium differed from the median intakes of these nutrients for specific sex and age groups, because values were not based on NHNS-J data. Our results indicate that 2 y of pooled data from the NHNS-J adequately reflect the population's intake, and that the current system for determination of AI values will be applicable for future revisions.

DOI： 10.3177/jnsv.59.584

Distribution of Vitamin E Intake among Japanese Dietary Supplement and Fortified Food Users: A Secondary Analysis from the National Health and Nutrition Survey, 2003-2009 査読

Megumi Tsubota-Utsugi, Makiko Nakade, Eri Imal, Nobuyo Tsuboyama-Kasaoka, Miho Nozue, Keizo Umegaki, Takeshi Yoshizawa, Nagako Okuda, Nobuo Nishi, Hidemi Takimoto

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 59 ( 6 ) 576 - 583 2013年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CENTER ACADEMIC PUBL JAPAN

This study was performed to: (1) assess the prevalence of dietary supplement and fortified food use, (2) examine the differences in vitamin E intake with and without dietary supplementation and/or fortified food use, and (3) determine whether some individuals consume vitamin E above the tolerable upper intake level (UL). Data were obtained from 64,624 individuals (age, >= 1 y; 47.4% males) who completed a 1-d household dietary assessment that was part of the National Health and Nutrition Survey conducted in Japan, 2003-2009. The survey also obtained information on the brand or generic name of each dietary supplement or fortified food reported, including their ingredients, through dietary assessment. The prevalence of a potential risk of excess was estimated by the proportion of persons above the age-/sex-specific ULs provided by the Dietary Reference Intakes for Japanese 2010. Supplement use was reported by 5.8% of men and 7.7% of women, whereas fortified food consumption was reported by only 2.9% of men and 3.6% of women. Use of dietary supplements was most common among older women, whereas use of fortified foods was most common among younger women. Both dietary supplement and fortified food use accounted for maximum vitamin E intake; however, the use of dietary supplements and fortified foods had little effect on the median and 95th percentile intake values. None of the subjects consumed nutrients above the UL. The collected data confirm that the use of both dietary supplements and fortified foods contributes a small amount to nutrient intake in Japanese subjects.

DOI： 10.3177/jnsv.59.576

Changes in B-Group Vitamin Status in Adenine-Induced Chronic Renal Failure Rats 査読

Eri Imai, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 77 ( 5 ) 1108 - 1110 2013年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

The purpose of this study was to determine the effects of chronic renal failure (CRF) on B-group vitamin status using model rats in which adenine-induced CRF. We measured B-groups vitamins in the urine, blood, liver, and kidney. These results showed that renal failure affected the distribution, metabolism, and renal clearance of water-soluble vitamins, and that the effects were different with each vitamin.

DOI： 10.1271/bbb.120941

Dietary reference intakes for Japanese 2010: Carbohydrates 招待

Kazuhiko Yamada, Nobuyo Tsuboyama-Kasaoka, Toshinao Goda, Kyoko Saito, Toshikazu Yamanouchi, Tetsuji Yokoyama, Osamu Chonan, Eri Imai, Makiko Nakade, Seiichiro Aoe

Journal of Nutritional Science and Vitaminology 59 S53 - S56 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

The Dietary Reference Intakes (DRIs) of carbohydrates and dietary fiber were determined for Japanese. The estimated average requirement (EAR) and recommended dietary allowance (RDA) for carbohydrates were not determined because of insufficient data. The tentative dietary goal for preventing lifestyle-related diseases (DG) for children aged 1 y and above was determined for carbohydrates (% energy). In addition, the DG for adults aged 18 y and above was determined for dietary fiber. Dietary fiber intake is associated with myocardial infarction
therefore, the DG was determined on the basis of the results of a meta-analysis and the median dietary fiber intake of Japanese. The DG for alcohol was not determined because of insufficient data.

DOI： 10.3177/jnsv.59.S53

Dietary Reference Intakes for Japanese 2010: Water-Soluble Vitamins 査読

Katsumi Shibata, Tsutomu Fukuwatari, Eri Imai, Takashi Hayakawa, Fumio Watanabe, Hidemi Takimoto, Toshiaki Watanabe, Keizo Umegaki

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 59 S67 - S82 2013年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CENTER ACADEMIC PUBL JAPAN

A potential approach for determining the estimated average requirement (EAR) is based on the observation that a water-soluble vitamin or its catabolite(s) can be detected in urine. In this approach, the urinary excretion of a water-soluble vitamin or its catabolite(s) increase when the intake exceeds the requirement. This approach is applied to vitamin B-1, vitamin B-2 and niacin. A second approach is to determine the blood concentration. In this case, the requirement is indicated by a value rather than a threshold level. The second approach is applied to vitamin B-6, vitamin B-12, folate, and vitamin C. The recommended dietary allowance (RDA) was calculated by multiplying the EAR by 1.2. For pantothenic acid and biotin, there were insufficient data for determining the EAR. Thus, adequate intakes were set based on food surveillance data.

Dietary Reference Intakes for Japanese 2010: Fat-Soluble Vitamins 査読

Kiyoshi Tanaka, Junji Terao, Yoshihiro Shidoji, Hiroshi Tamai, Eri Imai, Toshio Okano

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 59 S57 - S66 2013年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CENTER ACADEMIC PUBL JAPAN

We have determined the Dietary Reference Intakes for fat-soluble vitamins (vitamin A, vitamin D, vitamin E, and vitamin K) for the Japanese. Regarding vitamin A, the estimated average requirement (EAR) and the recommended dietary allowance (RDA) were defined for those aged 1 y old and over. For vitamin D, vitamin E, and vitamin K, the EAR or RDA was not adopted, because of the insufficient data available. Thus, the adequate intake (AI) was determined for those vitamins based on the food surveillance data and biomarkers for each vitamin. The AI for vitamin D was decided as the median intake of vitamin D in the population with a circulating 25-hydroxy vitamin D level which was high enough for bone health. The basis for the AT for vitamin E was the median intake of a-tocopherol in the healthy population considering the lack of unfavorable health consequences attributable to its deficiency. The AT for vitamin K was determined as the vitamin K intake, required to avoid blood coagulation abnormalities. The tolerable upper intake level (UL) was determined for vitamin A, vitamin D and vitamin E, but not for vitamin K, since no adverse effects have been reported even with its high dosage.

Dietary intake of nutrients with Adequate Intake values in the Dietary Reference Intakes for Japanese.

Tsuboyama-Kasaoka N, Takizawa A, Tsubota-Utsugi M, Nakade M,　Imai E, Kondo A, Yoshida K, Okuda N, Nishi N, Takimoto H

Journal of Nutritional Science and Vitaminology 59 584 - 595 2013年

Dietary reference intakes for Japanese 2010: Carbohydrates

Yamada K,　Tsuboyama-Kasaoka N, Goda T, Saito K, Yamanouchi T, Yokoyama T, Chonan O, Imai E, Nakade M,

Journal of Nutritional Science and Vitaminology 59 S53 - S56 2013年

Dietary Reference Intakes for Japanese 2010: Fat-soluble vitamins.

Tanaka K, Terao J, Shidoji Y, Tamai H, Imai E, Okano T

Journal of Nutritional Science and Vitaminology 59 S57 - S66 2013年

Dietary reference intakes for Japanese 2010: Water-soluble Vitamins.

Shibata K, Fukuwatari T, Imai E, Hayakawa T, Watanabe F, Takimoto H, Watanabe T, and Umegaki K

Journal of Nutritional Science and Vitaminology 59 S67 - S82 2013年

Evaluation of the prevalence of iodine intakes from four 3-day dietary records above the tolerable upper intake level in a Japanese population.

Tsubota-Utsugi M, Imai E, Nakade M, Matsumoto T, Tsuboyama-Kasaoka N, Nishi N, Tsubono Y

Journal of Nutritional Science and Vitaminology 59 310 - 316 2013年

Changes of B-group vitamin status in adenine-induced chronic renal failure rats.

Imai E, Sano M, Fukuwatari T, and Shibata K

Bioscience, Biotechnology, and Biochemistry 77 1108 - 1110 2013年

食事摂取基準の策定システム構築に関する研究～国内外のガイドラインの作成手順とレビューシステム～

今井絵理，坪田（宇津木）恵，中出麻紀子，笠岡（坪山）宜代

栄養学雑誌 71 S15 - S25 2013年

Historical overview of the establishment of Dietary Reference Intakes for Japanese.

Tsuboyama-Kasaoka N, T.Utsugi M, Imai E, Nakade M, Kasuga M

Journal of Nutritional Science and Vitaminology 59 S6 - S8 2013年

Systematic classification of evidence for Dietary Reference Intakes for Japanese 2010 (DRIs-J 2010) in adults and future prospects　of DRIs in Asian countries.

Nakade M, Imai E, Tsubota-Utsugi M, Tsuboyama-Kasaoka N, Takimoto H

Asia Pacific Journal of Clinical Nutrition 22 474 - 489 2013年

Distribution of vitamin E intake among Japanese dietary supplement and fortified food users: a secondary analysis from the National Health and Nutrition Survey, 2003-2009.

Tsubota-Utsugi M, Nakade M, Imai E, Tsuboyama-Kasaoka N, Nozue M, Umegaki K, Yoshizawa T, Okuda N, Nishi N, Takimoto H

Journal of Nutritional Science and Vitaminology 59 576 - 583 2013年

政府が策定する食事指針・ガイドにおける食事摂取基準の活用状況

孫田みなみ、笠岡(坪山)宜代、瀧沢あす香、坪田(宇津木)恵、今井絵理、岡純

栄養学雑誌 71 S56 - S63 2013年

Dietary reference intakes for Japanese 2010: Carbohydrates 査読

Yamada K, Tsuboyama-Kasaoka N, Goda T, Saito K, Yamanouchi T, Yokoyama T, Chonan O, Imai E, Nakade M

Journal of Nutritional Science and Vitaminology 59 S53 - S56 2013年

Systematic classification of evidence for Dietary Reference Intakes for Japanese 2010 (DRIs-J 2010) in adults and future prospects of DRIs in Asian countries. 査読

Nakade M, Imai E, Tsubota-Utsugi M, Tsuboyama-Kasaoka N, Takimoto H

Asia Pacific Journal of Clinical Nutrition 22 ( 474 ) 489 2013年

Historical overview of the establishment of Dietary Reference Intakes for Japanese. 査読

Tsuboyama-Kasaoka N, T.Utsugi M, Imai E, Nakade M, Kasuga M

Journal of Nutritional Science and Vitaminology 59 S6 - S8 2013年

Evaluation of the prevalence of iodine intakes from four 3-day dietary records above the tolerable upper intake level in a Japanese population. 査読

Tsubota-Utsugi M, Imai E, Nakade M, Matsumoto T, Tsuboyama-Kasaoka N, Nishi N, Tsubono Y

Journal of Nutritional Science and Vitaminology 59 310 - 316 2013年

Dietary reference intakes for Japanese 2010: Water-soluble Vitamins. 査読

Shibata K, Fukuwatari T, Imai E, Hayakawa T, Watanabe F, Takimoto H, Watanabe T, Umegaki K

Journal of Nutritional Science and Vitaminology 59 S67 - S82 2013年

Dietary Reference Intakes for Japanese 2010: Fat-soluble vitamins. 査読

Tanaka K, Terao J, Shidoji Y, Tamai H, Imai E, Okano T

Journal of Nutritional Science and Vitaminology 59 S57 - S66 2013年

The Urinary Excretory Ratio of Nicotinamide Catabolites Was Associated with the Conversion Ratio of Tryptophan to Nicotinamide in Growing Rats Fed a Niacin-Free 20% Casein Diet 査読

Katsumi Shibata, Eri Imai, Mitsue Sano, Tsutomu Fukuwatari

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76 ( 1 ) 186 - 188 2012年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

Weaning rats were fed a niacin-free 20% casein diet. Twenty-four-h-urine samples were collected, and nicotinamide and its catabolites were measured. A correlation was found between the urinary excretory ratio of nicotinamide catabolites (N-1-methyl-2-pyridone-5-carboxamide + N-1-methyl-4-pyridone-3-carboxamide)/N-1-methylnicotinamide and the tryptophan-nicotinamide conversion ratio during growing period of the rats. This indicates the possibility that the conversion ratio can be deduced from the excretory ratio.

DOI： 10.1271/bbb.110564

The urinary excretory ratio of nicotinamide catabolites is associated with the conversion ratio of tryptophan to nicotinamide in growing rats fed a niacin-free 20% casein diet.

Shibata K, Imai E, Sano M, Fukuwatari T

Bioscience, Biotechnology, and Biochemistry 76 186 - 188 2012年

Urinary excretion of water-soluble vitamins increases in streptozotocin-induced diabetic rats without decreases in liver and blood vitamin contents.

Imai E, Sano M, Fukuwatari T, Shibata K

Journal of Nutritional Science and Vitaminology 58 54 - 58 2012年

Urinary excretion of water-soluble vitamins increases in streptozotocin-induced diabetic rats without decreases in liver and blood vitamin contents. 査読

Imai E, Sano M, Fukuwatari T, Shibata K

Journal of Nutritional Science and Vitaminology 58 54 - 58 2012年

Relationship of homocysteine and homocysteine-related vitamins to bone mineral density in Japanese patients with type 2 diabetes 査読

Chizumi Yamada, Shimpei Fujimoto, Kaori Ikeda, Yuki Nomura, Ami Matsubara, Miwako Kanno, Kenichiro Shide, Kiyoshi Tanaka, Eri Imai, Tsutomu Fukuwatari, Katsumi Shibata, Nobuya Inagaki

JOURNAL OF DIABETES INVESTIGATION 2 ( 3 ) 233 - 239 2011年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Aims/Introduction:
To estimate nutritional risk factors for osteoporosis in patients with type 2 diabetes, bone mineral density, homocysteine level, and intakes and levels of Hcy-related vitamins including folate, vitamin B(6) and vitamin B(12) were analyzed in a cross-sectional study.
Materials and Methods:
Lumbar spine and femoral neck bone mineral density, serum concentrations of vitamin B(6), vitamin B(12), and folate and plasma homocysteine levels were measured in 125 Japanese patients with type 2 diabetes. Nutrient intake values were evaluated using a food frequency questionnaire.
Results:
Homocysteine was inversely correlated with bone mineral density, and with both dietary intake and serum concentration of folate. Intake of green vegetables was correlated with intake and level of folate and homocysteine levels. When the population was analyzed across the quartiles, bone mineral density, serum folate concentration, folate intake and intake of green vegetables were lowest in the highest homocysteine group.
Conclusions:
In patients with type 2 diabetes, the nutritional status of folate might affect the homocysteine level, a putative risk factor for osteoporosis. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00088.x, 2011).

DOI： 10.1111/j.2040-1124.2010.00088.x

ストレプトゾトシン誘導糖尿病ラットのトリプトファン－ニコチンアミド代謝 ―摂取ビタミン量との関係―:—摂取ビタミン量との関係—

Relationship of homocysteine and homocysteinerelated vitamins to bone mineral density in Japanese patients with type 2 diabetes.

Yamada C, Fujimoto S, Ikeda K, Nomura Y, Matsubara A, Kanno M, Shide K, Tanaka K, Imai E, Fukuwatari T, Shibata K, Inagaki N

Journal of Diabetes Investigation 2 233 - 239 2011年

ストレプトゾトシン誘発糖尿病ラットのトリプトファン－ニコチンアミド代謝－摂取ビタミン量との関係－

今井絵理，佐野光枝，福渡努，柴田克己

日本栄養・食糧学会誌 64 313 - 321 2011年

Association between 24 h urinary α-tocopherol catabolite, 2, 5, 7, 8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in intervention and cross-sectional studies.

Imai E, Tsuji T, Sano M, Fukuwatari T, Shibata K

Asia Pacific Journal of Clinical Nutrition 20 507 - 513 2011年

Association between 24 h urinary α-tocopherol catabolite, 2, 5, 7, 8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in intervention and cross-sectional studies. 査読

Imai E, Tsuji T, Sano M, Fukuwatari T, Shibata K

Asia Pacific Journal of Clinical Nutrition 20 ( 4 ) 507 - 513 2011年

今井絵理, 佐野光枝, 福渡努, 柴田克己

日本栄養・食糧学会誌 64 ( 5 ) 313 - 321 2011年

記述言語：日本語出版者・発行元：日本栄養・食糧学会

トリプトファン (Trp) の異化代謝にはビタミンB1, B2, B6が関わっている。そこで, 低用量, 中用量, 十分量のビタミン混合を含む飼料を投与した時にTrp異化代謝がどのように変動するのかを, 健常ラットと糖尿病ラットを用いて比較した。健常ラットにおいても, 糖尿病ラットにおいても, 飼料中のビタミン混合含量の差異はTrp異化代謝には全く影響をおよぼさなかった。糖尿病ラットにおけるTrp-ニコチンアミド (Nam) 転換率は健常ラットの1/3程度にまで低下していた。N1-メチルニコチンアミドが体内に蓄積しやすい代謝状態にあった。この現象は体内の遊離状態のNam濃度の上昇を引き起こす可能性がある。遊離型のNamは, poly (ADP-ribose) 合成酵素やヒストンデアセチラーゼなど種々の酵素の阻害剤である。したがって, 糖尿病時にはNam代謝変動による影響が表れる可能性があり, さらなる研究が必要である。

DOI： 10.4327/jsnfs.64.313

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