Faculty Profiles - KOSHIYAMA Masafumi

Papers - KOSHIYAMA Masafumi

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The effect of wearing elastic compression stockings on leg edema in pregnant women in late pregnancy as determined by measuring the deep venous velocity and flow. Reviewed International journal

Mori K, Koshiyama M,Watanabe Y, Okamoto N, Yanagisawa N, Banba A, Ikuta E, Ono A, Seki K, Nakagawa M, Sakamoto S, Hara Y, Nakashima A.

Healthcare 13 1 - 13 2025.1

Authorship：Corresponding author Language：English Publishing type：Doctoral thesis Publisher：MDPI Participation form：Joint(The main charge)

Background: The present study evaluated the objective effectiveness of wearing compression stockings during late pregnancy on leg edema by measuring changes in venous velocity and blood flow. Methods: Using Doppler ultrasonography, we calculated the popliteal venous velocity and blood flow and compared them in the following four groups: (1) 13 non-pregnant women (26 legs) without leg edema, (2) 23 pregnant women (46 legs) in late pregnancy without leg edema, (3) 22 pregnant women (44 legs) in late pregnancy with leg edema who were followed up without treatment, and (4) 21 pregnant women (42 legs) in late pregnancy with leg edema who wore elastic compression stockings for 1 week. Results: Both the average velocity and blood flow of the popliteal vein of pregnant women’s legs in late pregnancy were significantly lower than those in non-pregnant women (6.32 ± 0.28 cm/s vs. 9.14 ± 0.37 cm/s; 118.48 ± 8.83 mL/min vs. 177.73 ± 11.74 mL/min, p < 0.0001, respectively). Furthermore, both the average venous velocity and blood flow in edematous legs in late pregnancy were significantly lower than those in non-edematous legs (5.32 ± 0.93 cm/s vs. 6.32 ± 0.28 cm/s; 82.68 ± 35.90 mL/min vs. 118.48 ± 8.83 mL/min, p < 0.0001, respectively). Finally, both the average venous velocity and blood flow were significantly higher in edematous legs in late pregnancy after wearing stockings than without treatment (7.69 ± 0.17 cm/s vs. 5.36 ± 0.17 cm/s; 143.22 ± 48.74 mL/min vs. 97.03 ± 40.07 mL/min, p < 0.0001, respectively). Conclusions: The wearing of elastic compression stockings by women with edematous legs in late pregnancy significantly increases the deep venous velocity and flow. Thus, it is possible to prevent deep vein thrombosis in this population.

DOI： https://doi.org/10.3390/healthcare13030214

Ovarian cancer screening: where do we stand now? Reviewed International journal

Konishi I, Abiko K, Hayashi T, Koshiyama M, Matsumura M, Maba T, Yamanoi K, yamaguchi K, Hamanishi J, Mandai M.

Acad Oncol. 2 - 1-11 2025.1

Ovarian serous borderline tumors with recurrent or extraovarian lesions: a Japanese, retrospective, multi-institutional, population-based study. Reviewed

Baba T, Koshiyama M, Kagabu M, Mikami Y, Minamiguchi S, Moritani S, Ishikawa M, Okamoto A, Terao Y, Nakanishi T, Katabuchi H, Tokunaga H, Satoh T, Konishi I, Yaegashi N. 2023.8

A histogram analysis of the pixel grayscale (luminous intensity) of B-mode ultrasound images of the subcutaneous layer predicts the grade of leg edema in pregnant women. Reviewed

Ikuta E, Koshiyama M, Watanabe Y, Banba A, Yanagisawa N, Nakagawa M, Ono A, Seki K, Kambe H, Godo T, Sakamoto S, Hara Y, Nakajima A.

Healthcare ( 11 ) 1 - 9 2023.5

Measurement of skin thickness using ultrasonography to test the usefulness of elastic compression stocking for leg edema in pregnant women. Invited Reviewed International journal

Banba A, Koshiyama M, Watanabe Y, Makino K, Ikuta E, Yanagisawa N, Ono A, Nakagawa M, Seki K, Sakamoto S, Hara Y, Nakajima A.

Healthcare 10 2022.9

Basic study for the quantitative diagnosis of edema focusing on ultrasound propagation time waveform information. Reviewed International journal

Sakamoto S, Godo T, Koshiyama M, Ikuta E, Watanabe Y,

Women’s Health open journal. 8 9 - 18 2022.7

看護学系大学生の避妊行動に対する意識ならびに実態と性教育との関連 Reviewed

鈴木柚衣、森日香里、上野奈穂、菅沼信彦、清川加奈子、渡邊浩子、中塚幹也、越山雅文、大橋一友　

母性衛生 63 ( 2 ) 483 - 491 2022.7

The preventive effect of dietary antioxidants on viral infection (coronavirus disease-2019, influenza and human papillomavirus) and the development of cervical carcinogenesis. Reviewed International journal

Ikuta E, Koshiyama M, Nakagawa M, Ono A, Watanabe Y, Seki K, Oowaki M, Okuda Y

Women's Health open journal 7 ( 2 ) 34 - 37 2021.12

The preventive effect of dietary antioxidants on cervical cancer development. Invited Reviewed International journal

Ono A, Koshiyama M, Nakagawa M, Watanabe Y, Ikuta E, Seki K, Oowaki M.

Medicina 56 ( 0604 ) 1 - 12 2020.11

Measurement of women's leg edema using ultrasonography. Reviewed International journal

Ikuta E, Watanabe Y, Yanagisawa N, Nakagawa M, Ono A, Seki K, Oowaki M, Koshiyama M, Sakamoto S.

Women's Health open journal ( 6 ) - 7 2020.4

Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment. Reviewed International journal

Horikawa N, Abiko K, Matsumura N, Baba T, Hamanishi J, Yamaguchi K, Murakami R, Taki M, Ukita M, Hosoe Y, Koshiyama M, Konishi I, Mandai M.

Br J Cancer 2020.1

The preventive effect of dietary antioxidants against cervical cancer versus promotive effect of tobacco smoking. Reviewed International journal

Koshiyama M, Nakagawa M, Ono A.

Healthcare 7 ( 162 ) 1 - 6 2019.12

Relationship between tobacco smoking and cervical cancer. Invited Reviewed International journal

Ono A, Nakagawa M, Ikuta E, Watanabe Y, Koshiyama M

Women's Health open journal ( 5 ) 19 - 21 2019.11

Development and themes of diagnostic and treatment procedures for secondary leg lymphedema in patients with gynecologic cancers. Invited Reviewed International journal

Watanabe Y, Koshiyama M, Seki K, Nakagawa M, Ikuta E, Oowaki M, Sakamoto S.

Healthcare 7 ( 100 ) 1 - 18 2019.8

The effects of the dietary and nutrient intake on gynecologic cancers. Invited Reviewed International journal

Koshiyama M

Healthcare 7 ( 88 ) 2019.7

A quantitative method to measure skin thickness in leg edema in pregnant women using B-scan portable ultrasonography: A comparison between obese and non-obese women. Reviewed International journal

Yanagisawa N, Koshiyama M, Watanabe Y, Sato S, Sakamoto S

Med Sci Monit ( 25 ) 1 - 9 2019.1

Development and significance of "Mamin": A child-care record-keeping mobile application for parents. Reviewed International journal

Oowaki M, Iida Y, Koshiyama M

Women's Health open journal ( 4 ) 8 - 10 2018.10

The effect of the type of dietary protein on the development of ovarian cancer. Reviewed International journal

Taha AAA, Koshiyama M, Matsumura N, Abiko K, Yamaguchi K, Hamanishi J, Baba T, Kharma B, Mohamed IH, Ameen MM, Ismail SA, Konishi I, Mandai M

Oncotarget ( 9 ) 23987 - 23999 2018.5

Potential efficacy of anti-PD-1 or PD-L1 antibody treatments for gynecologic cancers. Invited Reviewed International journal

Koshiyama M

Women’s Health open journal ( 3 ) e21 - e23 2017.11

Exome sequencing landscape analysis in ovarian clear cell carcinoma shed light on key chromosomal regions and mutation gene networks. Reviewed International journal

Murakami R, Matsumura N, Brown JB, Higasa K, Tsutsumi T, Kamada M, Abou-Taleb H, Hosoe Y, Kitamura S, Yamaguchi K, Abiko K, Hamanishi J, Baba T, Koshiyama M, Okuno Y, Yamada R, Matsuda R, Konishi I, Mandai M

Am J Pathol ( 187 ) 2246 - 2258 2017.10

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Papers - KOSHIYAMA Masafumi