Faculty Profiles - NAKAGAWA Toshinori

Papers - NAKAGAWA Toshinori

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White poplar: Targeted isolation of pancreatic lipase inhibitors Reviewed

Elsbaey M., Amen Y., Nakagawa T., Shimizu K.

Industrial Crops and Products 141 2019.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Industrial Crops and Products

© 2019 Elsevier B.V. In order to discover new anti-obesity agents, twenty two natural extracts from medicinal plants and agricultural wastes were screened by pancreatic lipase inhibition assay. The methanolic extract of poplar wood (Populus alba L.), an important raw material for paper industry, showed promising inhibitory activity, its IC50 value was 7.15 μg/mL. Through bio-guided fractionation, the ethyl acetate fraction (E) was found to be the major contributor to the activity, IC50 = 4.7 μg/mL. Hence, it was subjected to bio-guided isolation and nine compounds (1–9) were identified from the active sub-fractions. The isolates were identified by means of one- and two-dimensional nuclear magnetic spectroscopy (1D, 2D-NMR), as well as high-performance liquid chromatography quadrupole time-of flight mass spectrometry (HPLC-QTOF-MS). (+)-Taxifolin (5) and (+)-ampelopsin (4) showed the highest activity, their IC50 values were 23.2 and 46.2 μM, respectively. The results indicated that flavonoids and phenolic acids in poplar wood could serve as potential candidates for development of new anti-obesity agents.

DOI： 10.1016/j.indcrop.2019.111778

Scopus

Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072326392&origin=inward

α-Glucosidase inhibitory activity of resin from sakhalin fir tree (abies sachalinensis) and its bioactive compounds Reviewed

Nakagawa T., Ashour A., Amen Y., Koba Y., Ohnuki K., Shimizu K.

Natural Product Communications 14 ( 6 ) 2019.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Natural Product Communications

© The Author(s) 2019 This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree (Abies sachalinensis). The resin showed extremely high activity (IC50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds-(holophyllane C (1), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4-seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−)-abiesonic acid 3-methyl ester (6))-showed high activity (their IC50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin's α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods.

DOI： 10.1177/1934578X19858460

Scopus

Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068613554&origin=inward

Antioxidant and anti-lipase compounds isolated from heartwood of Yakushima native cedar (Cryptomeria japonica) Reviewed

Nakagawa T., Ashour A., Amen Y., Ohnuki K., Fujimoto N., Shimizu K.

Journal of Wood Chemistry and Technology 2019.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Wood Chemistry and Technology

©, Copyright © Taylor & Francis Group, LLC. This article describes the biological activities of heartwood extracts from Yakushima native cedar (Cryptomeria japonica) and identifies their main active compounds. Black heartwood and red heartwood were each divided into two parts from the center (the pith) to outer heartwood (the cambium). The methanol extracts of those parts were screened for antioxidant and anti-lipase activities. The extract from the pith of the red heartwood showed the highest ORAC activity among the samples. Regarding anti-lipase activity, all the extracts showed relatively high activity (the IC 50 value were 9.71–37.24 μg mL −1 ). In addition, four compounds were isolated and identified from the pith of red heartwood by NMR and MS analyses. Agatharesinol (3) and sequirin C (4) were thought to be the main active compounds responsible for the antioxidant and anti-lipase activities.

DOI： 10.1080/02773813.2019.1578806

Scopus

Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063947924&origin=inward

佐賀県産農産物の魅力を掘り起こす〜コスメティック原料としての潜在能力〜

中川敏法, 清水邦義

FRAGRANCE JOURNAL 2019

A pilot study on the effects of Chrysanthemum scent on memory and mood Reviewed International journal

Francisca K., Shen X., Nakagawa T., Gianfagna T., Shimizu K., Goto S.

Journal of Therapeutic Horticulture 2019

Effect of geothermal drying treatment on extract composition of Sugi (Cryptomeria japonica) board Reviewed

65 ( 4 ) 195 - 200 2019

A new aliphatic ester of hydroxysalicylic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity Reviewed International journal

Ashour A., Amen Y.M., Nakagawa T., Niwa Y., Mira A., Ohnuki K., Murakami S., Imao M., Shimizu K.

Natural Product Research 2018.9

佐賀県で生産されたシキミ（Illicium anisatum）の機能性食品および化粧品素材としての機能性評価

中川敏法, 西條裕美, 石川洋哉, 泥谷慎司, 香月優, 岩元彬, 鶴田裕美, 柘植圭介, 吉村臣史, 大貫宏一郎, 清水邦義

日本食品保蔵科学会誌 2018.8

Biological activities of extracts from different parts of two cultivars of Prunus persica (L.) Batsch, `Akatsuki' and `Fastigiata' Reviewed International journal

Natural Product Communications 2018.7

Changes in content of triterpenoids and polysaccharides in Ganoderma lingzhi at different growth stages Reviewed International journal

Journal of Natural Medicines 2018.4

Potential activities for constituents from Vicia faba International journal

Trend in Phytochemical Research 2018.2

Effect of polyphenols from Vicia faba L on lipase activity and melanogenesis Reviewed International journal

Natural Product Research 2017.7

スギ材を内装材として使用した室内空間における揮発性成分の分析およびその季節変動

清水邦義, 吉村友里, 中川敏法, 松本清, 鷲岡ゆき, 羽賀栄理子, 本傳晃義, 中島大輔, 西條裕美, 藤田弘毅, 渡邊雄一郎, 岡本元一, 井上伸史, 安成信次, 永野純, 山田祐樹, 岡本剛, 大貫宏一郎, 石川洋哉, 藤本登留

日本木材学会誌 2017.5

乾燥処理がスギ板材の抽出成分に与える影響中温乾燥によるテルペン類の量的変化

奥田拓, 中川敏法, 村野朋哉, 三好悠, 亀井裕人, 佐々木隆雄, 三枝康弘, 和田善行, 湊俊司, 阪井彰一, 千里泰三, 藤本登留, 清水邦義

日本木材学会誌 2017.4

Improved biological activities of isoepoxypteryxin by biotransformation Reviewed International journal

Chemistry and Biodiversity 2016.9

Biological activities of extracts from different parts of Cryptomeria japonica Reviewed International journal

Natural Product Communications 2016.7

福岡県糸島産農産物の抗酸化活性を指標とした機能性評価

中川敏法, 永田敏郎, 大貫宏一郎, 森高正博, 福田晋, 清水邦義

九州大学農学芸誌 2016.5

Biological activities of oleanolic acid derivertives from Calendula officinalis Seeds Reviewed International journal

Phytotherapy Research 2016.5

エミューオイルの機能特性

南育子，中川敏法，室井由起子，奥野悦生，大貫宏一郎，清水邦義

九州栄養福祉大学研究紀要 13 149 - 152 2016

脂質への放射線照射による影響　揮発性物質の生成について

南育子，中川敏法，奥野悦生，大貫宏一郎，清水邦義

九州栄養福祉大学研究紀要 13 153 - 156 2016

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Papers - NAKAGAWA Toshinori