Updated on 2023/05/29

写真a

 
KUWAHARA Shoji
 
Organization
Faculty of Human Cultures
Department
School of Human Cultures Department of Nutrition
Title
Associate Professor
External link

Degree

  • 博士（栄養） ( 2012.2   徳島大学 )

Research Field

  • 栄養、腎臓

Research Experience

  • The University of Shiga Prefecture   School of Human Cultures Food Science and Nutrition Course   Associate Professor

    2021.7

  • The University of Shiga Prefecture   School of Human Cultures Food Science and Nutrition Course   Lecturer

    2019.4 - 2021.6

  • The University of Shiga Prefecture   School of Human Cultures Food Science and Nutrition Course   Assistant Professor

    2018.11 - 2019.3

Association Memberships

  • 日本栄養・食糧学会

    2018.12

Available Technology

  • リンの代謝調節機構の解明と健康

Papers

  • Rice Endosperm Protein Improves the Anti-Inflammatory Effects of High-Density Lipoprotein and Produces Lower Atherosclerotic Lesion Accelerated by the Renal Mass Reduction than Casein in a Mouse Model Reviewed International journal

    Ryohei Kaseda,Michihiro Hosojima,Shoji Kuwahara,Hideyuki Kabasawa,Hiroyuki Aoki,Yuki Higuchi,Valentina Kon,Ichiei Narita, Akihiko Saito

    Journal of the American Nutrition Association   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Efficacy of Low-Protein Rice for Dietary Protein Restriction in CKD Patients: A Multicenter, Randomized, Controlled Study Reviewed International journal

    Michihiro Hosojima, Hideyuki Kabasawa, Ryohei Kaseda, Tomomi Ishikawa-Tanaka, Yoshitsugu Obi, Toshiko Murayama, Shoji Kuwahara, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito

    Kidney360   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The vice charge)  

  • Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity Reviewed

    Arita M., Watanabe S., Aoki N., Kuwahara S., Suzuki R., Goto S., Abe Y., Takahashi M., Sato M., Hokari S., Ohtsubo A., Shoji S., Nozaki K., Ichikawa K., Kondo R., Hayashi M., Ohshima Y., Kabasawa H., Hosojima M., Koya T., Saito A., Kikuchi T.

    Scientific Reports   11 ( 1 )   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

    Cisplatin, one of the most active anticancer agents, is widely used in standard chemotherapy for various cancers. Cisplatin is more poorly tolerated than other chemotherapeutic drugs, and the main dose-limiting toxicity of cisplatin is its nephrotoxicity, which is dose-dependent. Although less toxic methods of cisplatin administration have been established, cisplatin-induced nephrotoxicity remains an unsolved problem. Megalin is an endocytic receptor expressed at the apical membrane of proximal tubules. We previously demonstrated that nephrotoxic drugs, including cisplatin, are reabsorbed through megalin and cause proximal tubular cell injury. We further found that cilastatin blocked the binding of cisplatin to megalin in vitro. In this study, we investigated whether cilastatin could reduce cisplatin-induced nephrotoxicity without influencing the antitumor effects of cisplatin. Nephrotoxicity was decreased or absent in mice treated with cisplatin and cilastatin, as determined by kidney injury molecule-1 staining and the blood urea nitrogen content. Combined with cilastatin, a twofold dose of cisplatin was used to successfully treat the mice, which enhanced the antitumor effects of cisplatin but reduced its nephrotoxicity. These findings suggest that we can increase the dose of cisplatin when combined with cilastatin and improve the outcome of cancer patients.

    DOI： 10.1038/s41598-020-80853-6

    Scopus

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099201373&origin=inward

  • Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: A prospective observational study Reviewed

    Shoji S., Hosojima M., Kabasawa H., Kondo R., Miura S., Watanabe S., Aoki N., Kaseda R., Kuwahara S., Tanabe N., Hirayama Y., Narita I., Kikuchi T., Kagamu H., Saito A.

    BMC Cancer   19 ( 1 )   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMC Cancer  

    © 2019 The Author(s). Background: Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake of cisplatin and resultant cisplatin-induced nephrotoxicity are mediated in part by megalin, an endocytic receptor in proximal tubule epithelial cells (PTECs). We also developed sandwich enzyme-linked immunosorbent assays to measure the megalin ectodomain (A-megalin) and full-length megalin (C-megalin) in urine using monoclonal antibodies against the amino- and carboxyl-termini of megalin, respectively. The present study examined the correlation of urinary megalin level with cisplatin-induced nephrotoxicity and its utility as a biomarker in patients with thoracic cancer. Methods: This prospective observational study involved 45 chemotherapy-naïve patients scheduled to receive chemotherapy with ≥60 mg/m2 cisplatin for histologically diagnosed small cell lung cancer, non-small cell lung cancer, or malignant pleural mesothelioma. Before and after the first course of chemotherapy, we measured urinary A- and C-megalin and other markers of PTEC injury, such as N-acetyl-β-D-glucosaminidase, α1-microglobulin, β2-microglobulin, neutrophil gelatinase-associated lipocalin, and liver-type fatty acid-binding protein, and compared the values with the change in the estimated glomerular filtration rate (eGFR) and clinical risk factors for renal impairment. Results: A negative correlation was found between baseline urinary A-megalin levels and change in eGFR (r = - 0.458, P = 0.002). According to Kaplan-Meier survival curves, eGFR decline was associated with the baseline urinary A-megalin quartile (P = 0.038). In addition, according to the hazard ratios (HRs) for eGFR decline > 10 mL/min/1.73 m2 calculated using a Cox proportional hazard model, the highest quartile had a significantly higher risk of eGFR decline compared with the lowest quartile (HR 7.243; 95% confidence interval 1.545-33.962). Other baseline urinary markers showed no correlation with eGFR decline. Conclusions: This is the first report demonstrating that prechemotherapy urinary A-megalin levels are correlated with the development of cisplatin-induced nephrotoxicity. This finding has clinical implications for the identification of patients at risk for cisplatin-induced nephrotoxicity and the development of possible prophylactic therapies.

    DOI： 10.1186/s12885-019-6398-2

    Scopus

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076083752&origin=inward

  • Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood Reviewed International journal

    Yuki Higuchi, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Sawako Goto, Koji Toba, Ryohei Kaseda, Takahiro Tanaka, Nobutaka Kitamura, Hayato Takihara, Shujiro Okuda, Masayuki Taniguchi, Hitoshi Arao, Ichiei Narita, Akihiko Saito

    Nutrients   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease Reviewed

    Toba K., Hosojima M., Kabasawa H., Kuwahara S., Murayama T., Yamamoto-Kabasawa K., Kaseda R., Wada E., Watanabe R., Tanabe N., Suzuki Y., Narita I., Saito A.

    BMC nephrology   20 ( 1 )   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMC nephrology  

    BACKGROUND: Dietary acid load has been suggested to mediate the progression of chronic kidney disease (CKD). However, it is unclear what kinds of foods are actually associated with dietary acid load in patients with CKD. The self-administered diet history questionnaire (DHQ), which semi-quantitatively assesses the dietary habits of Japanese individuals through 150 question items, can estimate average daily intake of various foods and nutrients during the previous month. Using the DHQ, we investigated the association of dietary acid load with CKD progression. We also analyzed the kinds of food that significantly affect dietary acid load. METHODS: Subjects were 96 outpatients with CKD (average estimated glomerular filtration rate [eGFR], 53.0 ± 18.1 ml/min/1.73 m2) at Niigata University Hospital, who had completed the DHQ in 2011. We calculated net endogenous acid production (NEAP) from potassium and protein intake evaluated by the DHQ in order to assess dietary acid load. CKD progression was assessed by comparing eGFR between 2008 and 2014. RESULTS: NEAP was not correlated with protein intake (r = 0.088, p = 0.398), but was negatively correlated with potassium intake (r = - 0.748, p < 0.001). Reduction in eGFR from 2008 to 2014 was estimated to be significantly greater in patients with higher NEAP (NEAP > 50.1 mEq/day, n = 45) than in those with lower NEAP (NEAP ≤50.1 mEq/day, n = 50) by 5.9 (95% confidence interval [95%CI], 0.1 to 11.6) ml/min/1.73 m2. According to multiple logistic regression analysis, higher NEAP was significantly associated with lower intake of fruits (odds ratio [OR], 6.454; 95%CI, 2.19 to 19.00), green and yellow vegetables (OR, 5.18; 95%CI, 1.83 to14.66), and other vegetables (OR, 3.87; 95%CI, 1.29 to 11.62). CONCLUSIONS: Elevated NEAP could be a risk factor for CKD progression. Low intake of fruits and vegetables would increase dietary acid load and might affect the progression of renal dysfunction in Japanese CKD patients.

    DOI： 10.1186/s12882-019-1591-8

    Scopus

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075524103&origin=inward

  • Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption. Reviewed International journal

    Suman Shrestha, Hiroaki Sunaga, Hirofumi Hanaoka, Aiko Yamaguchi, Shoji Kuwahara, Yogi Umbarawan, Kiyomi Nakajima, Tetsuo Machida, Masami Murakami, Akihiko Saito, Yoshito Tsushima, Masahiko Kurabayashi, Tatsuya Iso

    SCIENTIFIC REPORTS   2018.11

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The vice charge)  

  • A Randomized, Double-Blind, Crossover Pilot Trial of Rice Endosperm Protein Supplementation in Maintenance Hemodialysis Patients. Reviewed International journal

    Michihiro Hosojima, Hisaki Shimada, Yoshitsugu Obi, Shoji Kuwahara, Ryohei Kaseda, Hideyuki Kabasawa, Hazuki Kondo, Mikio Fujii, Reiko Watanabe, Yoshiki Suzuki, Motoni Kadowaki, Shigeru Miyazaki, Akihiko Saito

    SCIENTIFIC REPORTS   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity. Reviewed International journal

    Yoshihisa Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto, Tomomichi Iida, Shankhajit De, Hideyuki Kabasawa, Reika Kaneko, Hiroyuki Aoki, Yoshinari Tanabe, Hiroshi Kagamu, Ichiei Narita, Toshiaki Kikuchi, Akihiko Saito

    Journal of the American Society of Nephrology   2017.6

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. Reviewed International journal

    De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A

    Diabetes   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • SGLT2阻害薬開始前後で食事記録を確認できた肥満2型糖尿病患者の一例 Reviewed

    和田恵梨, 細島康宏, 蒲澤秀門, 石川友美, 桑原頌治, 忰田亮平, 成田一衛, 本間則行, 鈴木芳樹, 斎藤亮彦

    日本病態栄養学会誌   2017

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Participation form：Joint(The vice charge)  

  • Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease. Reviewed International journal

    Kuwahara S, Hosojima M, Kaneko R, Aoki H, Nakano D, Sasagawa T, Kabasawa H, Kaseda R, Yasukawa R, Ishikawa T, Suzuki A, Sato H, Kageyama S, Tanaka T, Kitamura N, Narita I, Komatsu M, Nishiyama A, Saito A

    Journal of the American Society of Nephrology   2016.7

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells. Reviewed International journal

    De S, Kuwahara S, Saito A

    Membranes   2014.7

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Dietary inorganic phosphorus regulates the intestinal peptide transporter PepT1. Reviewed International journal

    Furutani J, Segawa H, Aranami F, Kuwahara S, Sugano M, Bannai K, Yamato H, Ito M, Miyamoto K

    Journal of Renal Nutrition   2013.3

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c. Reviewed

    Kuwahara S, Aranami F, Segawa H, Onitsuka A, Honda N, Tominaga R, Hanabusa E, Kaneko I, Yamanaka S, Sasaki S, Ohi A, Nomura K, Tatsumi S, Kido S, Ito M, Miyamoto K

    THE JOURNAL OF MEDICAL INVESTIGATION   2012

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • リン酸トランスポーターをめぐる最近の話 Invited

    桑原頌治　他

    消化と吸収   2012

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Participation form：Joint(The main charge)  

  • Inorganic phosphate homeostasis in sodium-dependent phosphate cotransporter Npt2b⁺/⁻ mice. Reviewed International journal

    Ohi A, Hanabusa E, Ueda O, Segawa H, Horiba N, Kaneko I, Kuwahara S, Mukai T, Sasaki S, Tominaga R, Furutani J, Aranami F, Ohtomo S, Oikawa Y, Kawase Y, Wada NA, Tachibe T, Kakefuda M, Tateishi H, Matsumoto K, Tatsumi S, Kido S, Fukushima N, Jishage K, Miyamoto K.

    American Journal of Physiology-Renal Physiology   2011.11

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    Language：English   Publishing type：Research paper (scientific journal)   Participation form：Joint(The vice charge)  

  • Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies. Reviewed International journal

    Miyamoto K, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I, Segawa H.

    Journal of Pharmaceutical Sciences   2011

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  • Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters. Reviewed International journal

    Kaneko I, Segawa H, Furutani J, Kuwahara S, Aranami F, Hanabusa E, Tominaga R, Giral H, Caldas Y, Levi M, Kato S, Miyamoto K.

    Pflugers Archiv: European Journal of Physiology   2011

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  • Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice. Reviewed International journal

    Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami F, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto K.

    American Journal of Physiology-Renal Physiology   2010.6

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  • Fibroblast growth factor 23 mediates the phosphaturic actions of cadmium. Reviewed

    Aranami F, Segawa H, Furutani J, Kuwahara S, Tominaga R, Hanabusa E, Tatsumi S, Kido S, Ito M, Miyamoto K.

    THE JOURNAL OF MEDICAL INVESTIGATION   2010.2

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Books etc

  • エキスパート管理栄養士養成シリーズ基礎栄養学［第５版］

    坂井堅太郎　編（ Role： Joint author）

    化学同人  2021.2  （ ISBN:978-4-7598-2152-9 ）

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    Total pages：210   Responsible for pages：87‐101、189‐200   Language：Japanese   Book type：Textbook, survey, introduction

  • 糖尿病性腎症病期分類に基づいた腎病理診断の手引き

    和田隆志、湯澤由紀夫、乳原善文、古市賢吾　編集（ Role： Joint author）

    東京医学社  2019.4 

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    Language：Japanese   Book type：Report

MISC

  • 腎疾患におけるエクソソームバイオマーカー Invited

    細島康宏、蒲澤秀門、桑原頌治、斎藤亮彦

    CLINICAL CALCIUM   2018.2

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The vice charge)  

  • メガリンをターゲットとした慢性腎臓病の新規治療法の開発 Invited

    桑原頌治、細島康宏、蒲澤秀門、忰田亮平、斎藤亮彦

    腎と骨代謝   2018

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (bulletin of university, research institution)   Participation form：Joint(The main charge)  

  • メガリンを入り口とした腎障害機序とそれに基づく診断・治療法の開発 Invited

    桑原 頌治, 細島 康宏, 斎藤 亮彦

    臨床病理   2017

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • 腎障害の「入り口」分子としてのメガリン Invited

    桑原 頌治、細島 康宏、蒲澤 秀門、 忰田 亮平、斎藤 亮彦

    腎臓内科・泌尿器科   2017

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • 近位尿細管細胞と蛋白尿 Invited

    桑原頌治, 細島康宏, 忰田亮平, 斎藤亮彦

    腎と透析   2016

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • タンパク質代謝臓器としての腎 Invited

    富野康日己、柏原　直樹　他

    In: Annual Review 腎臓 2015   2015.1

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • メガリンとその関連分子をめぐる最近の話題 Invited

    富野 康日己, 成田 一衛, 柏原 直樹　他

    In: Annual Review 腎臓 2014   2014

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • メガリンとCKD Invited

    桑原　頌治 , 細島　康宏 , 斎藤　亮彦

    腎と骨代謝   2013.7

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • FGF23およびklothoによる尿細管でのリン輸送制御機構 Invited

    桑原頌治, 野村憲吾, 大井彰子, 宮本賢一

    腎と透析   2012

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The main charge)  

  • 栄養・食品機能とトランスポーター Invited

    竹谷豊、 薩秀夫、 伊藤美紀子、 武田英二 　他

    栄養・食品機能とトランスポーター   2011.5

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The vice charge)  

  • トランスポートソーム生体膜輸送機構の全体像に迫る～基礎、臨床、創薬応用研究の最新成果～ Invited

    金井 好克 　他

    遺伝子医学MOOK   2011.3

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    Language：Japanese   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)   Participation form：Joint(The vice charge)  

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