Updated on 2022/11/08

写真a

 
ENDO Hiroshi
 
Organization
Faculty of Human Cultures
Department
School of Human Cultures Department of Nutrition
Title
Associate Professor
External link

Education

  • The University of Tokushima   Graduate School, Division of Medicine

      More details

    Course completed: Doctor's Course

    Country: Japan

  • The University of Tokushima   Graduate School, Division of Medical Science

      More details

    Course completed: Master's Course

    Country: Japan

  • Yokohama National University   Faculty of Engineering

      More details

    Country: Japan

Degree

  • 博士(医学) ( 2009.3   徳島大学 )

Research Experience

  • The University of Shiga Prefecture   School of Human Cultures Food Science and Nutrition Course   Associate Professor

    2019.4

  • The University of Shiga Prefecture   School of Human Cultures Food Science and Nutrition Course   Assistant Professor

    2013.4 - 2019.3

Available Technology

  • 食品成分を基とした疾病の治療薬開発に向けて

Papers

  • Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax Reviewed

    Masaya Tanaka, Hiroshi Endo, Konatsu Sakusa, Mihiro Yano

    International Journal of Oncology   2022.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

    DOI: 10.3892/ijo.2022.5433

  • Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad Reviewed

    Endo H., Inoue I., Masunaka K., Tanaka M., Yano M.

    Bioscience, Biotechnology and Biochemistry   84 ( 12 )   2440 - 2447   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Bioscience, Biotechnology and Biochemistry   Participation form:Joint(The main charge)  

    The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade.

    DOI: 10.1080/09168451.2020.1808443

    Scopus

    Other Link: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089869160&origin=inward

  • C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice. Reviewed International journal

    Shirai T, Inoue O, Tamura S, Tsukiji N, Sasaki T, Endo H, Satoh K, Osada M, Sato-Uchida H, Fujii H, Ozaki Y, Suzuki-Inoue K.

    Journal of Thrombosis and Haemostasis.   2017.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

  • Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70. Reviewed

    Endo H, Yano M, Okumura Y, Kido H.

    Cell death & disease   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

  • Role of aromatic residues in amyloid fibril formation of human calcitonin by solid-state 13C NMR and molecular dynamics simulation. Reviewed

    Itoh-Watanabe H, Kamihira-Ishijima M, Javkhlantugs N, Inoue R, Itoh Y, Endo H, Tuzi S, Saitô H, Ueda K, Naito A.

    Physical chemistry chemical physics   2013.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

  • Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation. Reviewed

    Endo H, Ikeda K, Urano T, Horie-Inoue K, Inoue S.

    Journal of biochemistry   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

  • Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. Reviewed International journal

    Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, Kido H.

    Journal of NeuroVirology   2008.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The main charge)  

  • Gatekeeper role of 14-3-3tau protein in HIV-1 gp120-mediated apoptosis of human endothelial cells by inactivation of Bad. Reviewed International journal

    Yano M, Nakamuta S, Shiota M, Endo H, Kido H.

    AIDS   2007.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Participation form:Joint(The vice charge)  

▼display all

Awards

  • 日本生化学会JB論文賞

    2013.10   日本生化学会   Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation

    H. Endo, K. Ikeda, T. Urano, K. Horie-Inoue and S. Inoue

     More details

    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

Presentations

  • クルクミンが有する癌細胞転移に対する抑制機能についての解析

    黒川沙貴,遠藤弘史,矢野仁康

    第94回日本生化学会大会  2021.11 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • ヘスペレチンはHSF1を介して癌細胞の上皮間葉転換を抑制する

    田中大也,遠藤弘史,矢野仁康

    第94回日本生化学会大会  2021.11 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • ヘスペレチンはHSF1の発現を抑制して肺癌幹細胞特性を低下させる

    佐草 小夏, 田中 大也, 遠藤 弘史, 矢野 仁康

    第93回日本生化学会大会  2020.9 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • クルクミンによる浮遊癌細胞に対するアノイキス誘導メカニズムの解析ならびに癌幹細胞抑制効果の検討

    舛中貴美子, 遠藤弘史, 矢野仁

    第92回日本生化学会大会  2019.9 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • ヘスペレチンの癌細胞及び癌幹細胞に対する新規抗癌作用の検討

    佐草小夏, 遠藤弘史, 矢野仁康

    第92回日本生化学会大会  2019.9 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • カプサイシンによるp53-14-3-3σ経路を介した細胞周期停止機能についての解析

    高台絢加, 遠藤弘史, 矢野仁康

    第92回日本生化学会大会  2019.9 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • クルクミンによる癌細胞死誘導メカニズムの解析ならびに浮遊癌細胞に対するアノイキス誘導効果の検討 Invited

    舛中 貴美子、遠藤 弘史、柘植 未来、矢野 仁康

    第73回日本栄養・食糧学会大会  2019.5 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

  • カプサイシンによる新規癌細胞増殖抑制機構:14-3-3σ を介した細胞周期停止機能についての解析

    高台 絢加、遠藤 弘史、日馬 亜希、矢野 仁康

    第73回日本栄養・食糧学会大会  2019.5 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

  • ヘスペレチンの新規抗癌作用:癌細胞と癌幹細胞を標的とした解析 Invited

    遠藤弘史

    ヘスペリジン研究会第10回研究発表会  2018.12 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • Ibuprofen Increases Cisplatin-induced Apoptosis in Lung Adenocarcinoma by Suppressing Hsp70 International conference

    矢野仁康,遠藤弘史,木戸博

    BMB2008  2008.12 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Diclofenac exerts anti-tumor activity via 14-3-3 proteins-dependent activation of mitochondrial apoptosis pathway International conference

    H. Endo, M. Yano, H. Kido

    The Gordon Research Conference on the “Biology of 14-3-3 Proteins”  2008.2 

     More details

    Language:English   Presentation type:Poster presentation  

  • Diclofenac exerts anti-tumor activity via 14-3-3 proteins-dependent activation of mitochondrial apoptosis pathway. International conference

    遠藤弘史,矢野仁康,木戸博

    BMB2007  2007.12 

     More details

    Language:Japanese   Presentation type:Oral presentation (general)  

▼display all